Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5529
Title: Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart
Authors: Silva, Moacir Paranhos
Pontes-de-Carvalho, Lain Carlos
Oliveira, Geraldo Gileno de Sá
Nascimento, Eliane Góes
dosSantos, Washington Luis Conrado
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Centro de Referência em Doenças Endêmicas Pirajá da Silva. Jequié, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Positive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In this work it is shown that a large proportion of dogs (11 out of 56) examined in an endemic area of leishmaniasis presented induration at the site of injection of a diluent containing thimerosal alone. This clearly demonstrates that thimerosal leads to a high number of false positive skin reactions in dogs and that its use in Montenegro's skin test antigenic preparations should be avoided
Keywords: Montenegro’s skin test
Leishmania
Delayed type hypersensitivity
Thimerosal
Canine visceral leishmaniasis
DeCS: Doenças do Cão/diagnóstico
Leishmania/imunologia
Leishmaniose/veterinária
Conservantes Farmacêuticos/efeitos adversos
Pele/efeitos de drogas
Timerosal/efeitos adversos
Animais
Brasil/epidemiologia
Doenças do Cão/epidemiologia
Doenças do Cão/imunologia
Doenças Endêmicas
Reações Falso-Positivas
Hipersensibilidade/imunologia
Hipersensibilidade/veterinária
Leishmaniose/diagnóstico
Leishmaniose/epidemiologia
Pele/imunologia
Pele/patologia
Testes Cutâneos
Issue Date: 2001
Citation: PARANHOS-SILVA, M. et al. Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart. Memórias do Instituto Oswaldo Cruz, v. 96, n. 5, p. 679-81, July 2001.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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