Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5531
Title: Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism.
Authors: Soares, Milena Botelho Pereira
Mota, Kátia N. Silva
Lima, Ricardo Santana de
Bellintani, Moema Cortizo
Pontes-de-Carvalho, Lain Carlos
Santos, Ricardo Ribeiro dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Chronic chagasic cardiomyopathy (CChC) is characterized by an inflammatory reaction which may eventually lead to heart enlargement, arrythmia, and death. As described herein, interleukin-4-deficient mice mount increased specific T helper (Th) 1 immune responses when infected with Trypanosoma cruzi, as compared to wild-type mice. Interestingly, these mice had reduced parasitism and mortality and exacerbated inflammation in their hearts, demonstrating a clear dissociation between inflammation and parasite load. The modulation of these phenomena so as to maximize host and parasite survivals may depend on a fine balance between Th responses, in which a Th1 response will, on one hand, control parasitism and, on the other hand, enhance heart inflammation throughout the course of the infection
DeCS: Cardiomiopatia Chagásica/imunologia
Inflamação/imunologia
Interleucina-4/fisiologia
Parasitemia/imunologia
Linfócitos T Auxiliares-Indutores/imunologia
Animais
Cardiomiopatia Chagásica/genética
Cardiomiopatia Chagásica/patologia
Imunidade Inata/genética
Imunidade Inata/imunologia
Inflamação/patologia
Interleucina-4/deficiência
Interleucina-4/genética
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Camundongos Nus
Miocardite/genética
Miocardite/imunologia
Miocardite/patologia
Parasitemia/patologia
Fatores de Tempo
Trypanosoma cruzi
Issue Date: 2001
Citation: SOARES, M.B. et al. Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. American Journal of Pathology, v. 159, n. 2, p. 703-709, Aug. 2001.
ISSN: 0002-9440
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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