| Author | Marques, Cintia Rodrigues | |
| Author | Fiuza, Bianca Sampaio Dotto | |
| Author | Silva, Thiago Magalhães da | |
| Author | Carneiro, Tamires Cana Brasil | |
| Author | Costa, Ryan Santos | |
| Author | Silva, Monica Francisca de Assis | |
| Author | Viana, Wagma Lauane Luz | |
| Author | Carneiro, Valdirene Leão | |
| Author | Neves, Neuza Maria Alcantara | |
| Author | Barreto, Maurício Lima | |
| Author | Figueiredo, Camila Alexandrina | |
| Access date | 2022-12-22T12:11:12Z | |
| Available date | 2022-12-22T12:11:12Z | |
| Document date | 2022 | |
| Citation | MARQUES, Cintia Rodrigues et al. Impact of FOXP3 gene polymorphisms and gene-environment interactions in asthma and atopy in a Brazilian population. Gene, v. 838, p. 1-6, 2022. | en_US |
| ISSN | 0378-1119 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/56153 | |
| Sponsorship | Ministério da Saúde e Departamento de Ciência e Tecnologia (DECIT).
Ministério da Ciência e Tecnologia, Fundo Nacional para o Desenvolvimento Científico e Desenvolvimento Tecnológico (FNDCT) e Financiamento de Estudos e Projetos (FINEP). | en_US |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Asma | en_US |
| Subject in Portuguese | Atopia | en_US |
| Subject in Portuguese | Foxp3 | en_US |
| Subject in Portuguese | Polimorfismos | en_US |
| Title | Impact of FOXP3 gene polymorphisms and gene-environment interactions in asthma and atopy in a brazilian population | en_US |
| Type | Article | en_US |
| DOI | 10.1016/j.gene.2022.146706 | |
| Abstract | Background: Polymorphisms in genes related to the activation and development of regulatory T cells (Tregs), such as FOXP3, may be associated with asthma and atopy development. Additionally, environmental factors such as exposure to infections can modify the effect of these associations. This study evaluated the impact of polymorphisms in the FOXP3 on the risk of asthma and atopy as also gene-environment interactions in these outcomes. Methods: This study included 1,246 children from the SCAALA program, between 4 and 11 years of age. DNA was extracted from peripheral blood and eight SNPs (rs2280883, rs11465476, rs11465472, rs2232368, rs3761549, rs3761548, rs2232365 and rs2294021) were genotyped using the 2.5 HumanOmni Beadchip from Illumina (San Diego, California, USA) or TaqMan qRT-PCR. Results: The rs2232368 (Allele T) was positively associated with asthma symptoms (OR = 1.95, CI = 1.04 to 3.66, p = 0.040) and skin prick test (SPT) reactivity to aeroallergens (OR = 2.31, CI = 1.16 to 4.59, p = 0.017). The rs3761549 (Allele T) was positively associated with SPT reactivity (OR = 1.44, CI = 1.03 to 2.02, p = 0.034). The rs2280883 (Allele C) was negatively associated with specific IgE to aeroallergens (OR = 0.83, CI = 0.70 to 0.99, p = 0.040). Furthermore, the rs2280883 played a protective role in the development of atopy only in individuals seropositive to Epstein-Barr virus (EBV) infection (OR = 0.74, CI = 0.60 to 0.92, p = 0.003 and OR = 0.74; 95% CI = 0.61–0.91, p = 0.007 for SPT and slgE respectively), but not in individuals without EBV infection. Conclusion: Polymorphisms in the FOXP3 gene were associated with the risk of atopy and asthma development in our population. In addition, EBV infection had an effect modifier of the observed association for rs2280883 variant. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto Multidisciplinar de Saúde. Vitória da Conquista, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Jequié, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde, Salvador, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Subject | Asthma | en_US |
| Subject | Atopy | en_US |
| Subject | Foxp3 | en_US |
| Subject | Polymorphisms | en_US |
| DeCS | Asma | en_US |
| DeCS | Variações do Número de Cópias de DNA | en_US |
