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SARS‐COV‐2 GENOMIC MONITORING IN THE STATE OF SÃO PAULO UNVEILS TWO EMERGING AY.43 SUBLINEAGES
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Abstract
Delta VOC is highly diverse with more than 120 sublineages already described as of
November 30, 2021. In this study, through active monitoring of circulating severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) variants in the state of São Paulo,
southeast Brazil, we identified two emerging sublineages from the ancestral AY.43 strain
which were classified as AY.43.1 and AY.43.2. These sublineages were defined by the
following characteristic nonsynonymous mutations ORF1ab:A4133V and ORF3a:T14I for
the AY.43.1 and ORF1ab:G1155C for the AY.43.2 and our analysis reveals that they
might have a likely‐Brazilian origin. Much is still unknown regarding their dissemination in
the state of São Paulo and Brazil as well as their potential impact on the ongoing
vaccination process. However, the results obtained in this study reinforce the importance
of genomic surveillance activity for timely identification of emerging SARS‐CoV‐2 variants
which can impact the ongoing SARS‐CoV‐2 vaccination and public health policies.
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