Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5627
Title: Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice.
Authors: Souza, Valderes Lemos de
Souza, Juliana Ascenção
Silva, Tânia Maria Correia
Veras, Patrícia Sampaio Tavares
Freitas, Luiz Antonio Rodrigues de
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Most experimental studies on leishmaniasis compare two different inbred strains of mice that are resistant or susceptible to one species of Leishmania. In the present study we characterized some cytokines and nitric oxide production as well as histological changes related to resistance and susceptibility in isogenic CBA mice infected with Leishmania major or Leishmania amazonensis. CBA mice are capable of controlling infection with L. major, but they succumb to infection with L. amazonensis. Cells from susceptible L. amazonensis-infected CBA mice produced interleukin (IL)-4 and IL-10 but no interferon (IFN)-γ. On the other hand, resistant L. major-infected CBA mice produced IFN-γ and IL-10, but IL-4 was detected only in the first week of infection. Histopathological studies showed patterns of tissue responses at the site of the infection and in the draining lymph nodes that correlated with resistance or susceptibility. Resistant mice showed a mixed inflammatory cell infiltration and granulomas in the lesions, whereas in susceptible mice only heavily parasitized macrophages were seen. Our results indicate an important role of the parasite species in determining the pattern of immune response. L. amazonensis induces a Th2-type immune response, whereas L. major induces a Th1-type response. These factors must be identified and taken into account in the strategies for the development of vaccines against leishmaniasis. The model presented here will be useful for the study of such factors.
Keywords: CBA
Leishmaniasis
Histopathology
Immunology
Leishmania amazonensis
Leishmania major
DeCS: Leishmania major/patogenicidade
Leishmania/patogenicidade
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/patologia
Animais
Células Cultivadas
Citocinas/biossíntese
Leishmaniose Cutânea/parasitologia
Linfonodos/citologia
Linfonodos/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos CBA
Óxido Nítrico/biossíntese
Pele/patologia
Issue Date: 2000
Citation: LEMOS de SOUZA, V. et al. Different Leishmania species determine distinct profiles of immune and histopathological responses in CBA mice. Microbes and Infection, v. 2, n. 15, p. 1807-15, dec. 2000.
ISSN: 1286-4579
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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