Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5635
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dc.contributor.authorSoares, Milena Botelho Pereira
dc.contributor.authorSantos, Ricardo Ribeiro dos
dc.date.accessioned2012-10-03T19:26:48Z
dc.date.available2012-10-03T19:26:48Z
dc.date.issued1999
dc.identifier.citationSOARES, Milena Botelho Pereira; SANTOS, Ricardo Ribeiro do. Immunopathology of cardiomyopathy in the experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, Suppl 1, p. 257-262, 1999.
dc.identifier.issn0074-0276
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/5635
dc.language.isoeng
dc.rightsopen access
dc.titleImmunopathology of cardiomyopathy in the experimental Chagas disease
dc.typeArticle
dc.description.abstractenThe mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment. During the acute phase, the neuronal and cardiac fiber destruction occurs when ruptured parasite nests release T. cruzi antigens that bind to the cell surface in the vicinity which become targets for the cellular and humoral immune response against T. cruzi. The various factors involved in the genesis of autoimmunity in chronic T. cruzi infection include molecular mimicry, presentation of self-antigens and imbalance of immune regulation.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
dc.subject.enCardiomyopathy
dc.subject.enImmunopathology
dc.subject.enChagas disease
dc.subject.enTrypanosoma cruzi
dc.subject.decsAuto-Imunidade/imunologia
dc.subject.decsCardiomiopatia Chagásica/imunologia
dc.subject.decsTrypanosoma cruzi/imunologia
dc.subject.decsAnimais
dc.subject.decsLinfócitos T CD4-Positivos/imunologia
dc.subject.decsLinfócitos T CD8-Positivos/imunologia
dc.subject.decsLinhagem Celular
dc.subject.decsCardiomiopatia Chagásica/patologia
dc.subject.decsCamundongos
dc.subject.decsCamundongos Endogâmicos BALB C
dc.subject.decsCamundongos Nus
dc.subject.decsMiocárdio/imunologia
dc.subject.decsMiocárdio/patologia
dc.subject.decsNeurônios/imunologia
dc.subject.decsNeurônios/patologia
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