Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5639
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dc.contributor.authorSilva, Luciana Menezes da
dc.contributor.authorFernandes, André L. M
dc.contributor.authorBarbosa Junior, Aryon de Almeida
dc.contributor.authorOliveira, Irismar Reis de
dc.contributor.authorAndrade, Zilton de Araújo
dc.date.accessioned2012-10-03T21:15:58Z
dc.date.available2012-10-03T21:15:58Z
dc.date.issued2000
dc.identifier.citationSILVA, L.M. et al. Significance of schistosomal granuloma modulation. Memórias do Instituto Oswaldo Cruz, v. 95, n. 3, p.353-61, may-jun. 2000.
dc.identifier.issn0074-0276
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/5639
dc.language.isoeng
dc.rightsopen access
dc.titleSignificance of schistosomal granuloma modulation
dc.typeArticle
dc.description.abstractenHepatic Schistosoma mansoni periovular granulomas undergo changes in size, cellular composition and appearance with time. This phenomenon, known as "immunological modulation", has been thought to reflect host immunological status. However, as modulation has not been observed outside the liver, participation of local factors, hitherto little considered, seems crucial. Components of the extracellular matrix of periovular granulomas of the mouse were particularly studied in three different organs (liver, lung and intestine) and during three periods of infection time (acute, intermediate and chronic) by means of histological, biochemical and immunofluorescence techniques, while quantitative data were evaluated by computerized morphometry, in order to investigate participation of local factors in granuloma modulation. Results confirmed modulation as a exclusively hepatic phenomenon, since pulmonary and intestinal granulomas, formed around mature eggs, did not change size and appearance with time. The matricial components which were investigated (Type I, III and IV collagens, fibronectin, laminin, proteoglycans and elastin) were found in all granulomas and in all organs examined. However, their presence was much more prominent in the liver. Elastin was only found in hepatic granulomas of chronic infection. The large amount of extracellular matrix components found in hepatic granulomas was the main change responsible for the morphological aspects of modulation. Therefore, the peculiar environment of the liver ultimately determines the changes identified in schistosomal granuloma as "modulation".
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enModulation
dc.subject.enGranuloma
dc.subject.enShistosomiasis
dc.subject.enExtracellular matrix
dc.subject.decsGranuloma/patologia
dc.subject.decsEnteropatias Parasitárias/patologia
dc.subject.decsHepatopatias Parasitárias/patologia
dc.subject.decsPneumopatias Parasitárias/patologia
dc.subject.decsSchistosoma mansoni/imunologia
dc.subject.decsEsquistossomose mansoni/patologia
dc.subject.decsAnimais
dc.subject.decsMatriz Extracelular
dc.subject.decsFeminino
dc.subject.decsGranuloma/imunologia
dc.subject.decsGranuloma/parasitologia
dc.subject.decsEnteropatias Parasitárias/imunologia
dc.subject.decsEnteropatias Parasitárias/parasitologia
dc.subject.decsHepatopatias Parasitárias/imunologia
dc.subject.decsHepatopatias Parasitárias/parasitologia
dc.subject.decsPneumopatias Parasitárias/imunologia
dc.subject.decsMasculino
dc.subject.decsCamundongos
dc.subject.decsContagem de Ovos de Parasitas
dc.subject.decsEsquistossomose mansoni/imunologia
dc.subject.decsEsquistossomose mansoni/parasitologia
dc.subject.decsFatores de Tempo
Appears in Collections:BA - IGM - Artigos de Periódicos

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