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TRANSCRIPTIONAL ANALYSIS FOR TUBERCULOSIS IN PREGNANT WOMEN FROM THE PREGNANCY ASSOCIATED CHANGES IN TUBERCULOSIS IMMUNOLOGY (PRACHITI) STUDY
Mathad, Jyoti S. et al. | Date Issued: 2022
Author
Mathad, Jyoti S.
Queiroz, Artur T. L.
Bhosale, Ramesh
Alexander, Mallika
Naik, Shilpa
Kulkarni, Vandana
Andrade, Bruno B.
Gupta, Amita
Affilliation
Center for Global Health. Weill Cornell Medicine. New York, New York, USA.
2 Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Byramjee Jeejeebhoy Government Medical College–Sassoon Government Hospital. Pune, India / Byramjee Jeejeebhoy Government Medical College–Johns Hopkins University Clinical Trials Unit. Pune, India.
Byramjee Jeejeebhoy Government Medical College–Johns Hopkins University Clinical Trials Unit. Pune, India.
Byramjee Jeejeebhoy Government Medical College–Sassoon Government Hospital. Pune, India / Byramjee Jeejeebhoy Government Medical College–Johns Hopkins University Clinical Trials Unit. Pune, India.
Byramjee Jeejeebhoy Government Medical College–Johns Hopkins University Clinical Trials Unit. Pune, India.
Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.
Byramjee Jeejeebhoy Government Medical College–Johns Hopkins University Clinical Trials Unit. Pune, India / Division of Infectious Diseases. Johns Hopkins University School of Medicine. Baltimore, Maryland, USA.
Abstract
A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and one for TB progression (AUC = 0.96).
Keywords in Portuguese
Tuberculose
Gravidez
Assinatura de RNA
Transcriptômica
Imunologia
 
Keywords
Tuberculosis
Pregnancy
RNA signature
Transcriptomics
Immunology
 
DeCS
Tuberculose
Gravidez
RNA
Imunologia
 
Publisher
Oxford University Press
Citation
MATHAD, Jyoti S. et al. Transcriptional analysis for tuberculosis in pregnant women from the pregnancy associated changes in tuberculosis immunology (PRACHITi) study. Clinical Infectious Diseases, v. 75, p. 1-4, 2022.
DOI
10.1093/cid/ciac437
ISSN
1537-6591