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Title: Efeito da quimioterapia sobre os ovos do Schistosoma mansoni.
Authors: Reis, Mitermayer Galvão dos
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Praziquantel administered to mice with Schistosoma mansoni infection (50 cercarias/8 weeks) was observed to cause death of adult worms and disintegration of the eggs trapped within granulomas, sometimes with calcification, after the 4th day of treatment. Combined administration of oxamniquine/hycanthone to animals similarly infected, although quite effective in killing adult worms, did not interfere with the eggs in the tissue. The miracidium eclosion test was positive up to the 15th day after the curative treatment of these animals. Since praziquantel treatment causes a rapid destruction of eggs, possible serological and pathogenic effects are expected that may enable a faster reabsorption of granulomas by the host tissues than that produced by other equally effective drugs.
Keywords: Chemotherapy
Schistosoma Mansoni
DeCS: Óvulo/efeitos de drogas
Schistosoma mansoni/efeitos de drogas
Esquistossomose mansoni/quimioterapia
Quimioterapia Combinada
Issue Date: 1987
Citation: REIS, M.G. dos; ANDRADE, Z.A. Efeito da quimioterapia sobre os ovos do Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 82, n. 2, p. 161-5, apr.-jun. 1987.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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