Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5736
Title: Efeito da quimioterapia sobre os ovos do Schistosoma mansoni.
Authors: Reis, Mitermayer Galvão dos
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Praziquantel administered to mice with Schistosoma mansoni infection (50 cercarias/8 weeks) was observed to cause death of adult worms and disintegration of the eggs trapped within granulomas, sometimes with calcification, after the 4th day of treatment. Combined administration of oxamniquine/hycanthone to animals similarly infected, although quite effective in killing adult worms, did not interfere with the eggs in the tissue. The miracidium eclosion test was positive up to the 15th day after the curative treatment of these animals. Since praziquantel treatment causes a rapid destruction of eggs, possible serological and pathogenic effects are expected that may enable a faster reabsorption of granulomas by the host tissues than that produced by other equally effective drugs.
Keywords: Chemotherapy
Miracidium
Schistosoma Mansoni
Praziquantel
Oxamniquine/hycanthone
DeCS: Óvulo/efeitos de drogas
Praziquantel/farmacologia
Schistosoma mansoni/efeitos de drogas
Esquistossomose mansoni/quimioterapia
Animais
Quimioterapia Combinada
Feminino
Hicantone/farmacologia
Masculino
Camundongos
Oxamniquine/farmacologia
Issue Date: 1987
Citation: REIS, M.G. dos; ANDRADE, Z.A. Efeito da quimioterapia sobre os ovos do Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 82, n. 2, p. 161-5, apr.-jun. 1987.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
dos Reis MG Effect of chemotherapy....pdf219.47 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.