Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5738
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dc.contributor.authorAndrade, Sonia Gumes
dc.contributor.authorSadigursky, Moysés
dc.date.accessioned2012-10-26T17:57:46Z
dc.date.available2012-10-26T17:57:46Z
dc.date.issued1987
dc.identifier.citationANDRADE, S.G.; SADIGURSKY, M. The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations. Memórias do Instituto Oswaldo Cruz, v. 82, n. 1, p. 59-66, jan.-mar. 1987.
dc.identifier.issn0074-0276
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/5738
dc.language.isoeng
dc.rightsopen access
dc.titleThe conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
dc.typeArticle
dc.description.abstractenChronic focal and diffuse myocarditis with interstitial fibrosis developed in Swiss outbred mice and in the inbred AKR and A/J strains of mice which were chronically infected with several Trypanosoma cruzi strains belonging to three biological types (Type I, II and III). High incidence of electrocardiographic changes with predominance of intraventricular conduction disturbances, 1st. and 2nd. degree AV block, arrhythmias, comparable with those found in human Chagas' disease, were also present. Morphological study of the conduction tissue of the heart revealed inflammatory and fibrotic changes. The presence of inflammation in the inter-atrial septum almost always coincided with the inflammatory involvement of the ventricular conduction system. Focal inflammation was associated with vacuolization and focal necrosis of the specific fibers. Most of the lesions were seen affecting the His bundle (76.3% of the cases), the right bundle branch (73.3%), AV node (43.9%) and left bundle branch (37.5%). Correlation between morphological changes in the conduction tissue and electrocardiographic alteration occurred in 53.0 to 62.5% of the cases, according to the experimental groups.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enConduction system of the heart
dc.subject.enTrypanosoma cruzi
dc.subject.enChronic myocarditis
dc.subject.enChronic T. cruzi
dc.subject.enInfection in mice
dc.subject.enElectrocardiogram in mice
dc.subject.decsCardiomiopatia Chagásica/fisiopatologia
dc.subject.decsEletrocardiografia
dc.subject.decsSistema de Condução Cardíaco/fisiopatologia
dc.subject.decsMiocárdio/patologia
dc.subject.decsAnimais
dc.subject.decsBloqueio Cardíaco/patologia
dc.subject.decsCamundongos
dc.subject.decsCamundongos Endogâmicos A
dc.subject.decsCamundongos Endogâmicos AKR
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