Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5792
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dc.contributor.authorRodrigues, Claudiney Melquíades
dc.contributor.authorValadares, Helder Magno Silva
dc.contributor.authorFrancisco, Amanda Fortes
dc.contributor.authorArantes, Jerusa Marilda
dc.contributor.authorCampos, Camila França
dc.contributor.authorCarvalho, Andréa Teixeira de
dc.contributor.authorMartins Filho, Olindo Assis
dc.contributor.authorAraújo, Márcio Sobreira Silva
dc.contributor.authorArantes, Rosa Maria Esteves
dc.contributor.authorChiari, Égler
dc.contributor.authorFranco, Glória Regina
dc.contributor.authorMachado, Carlos Renato
dc.contributor.authorPena, Sérgio Danilo Junho
dc.contributor.authorFaria, Ana Maria Caetano de
dc.contributor.authorMacedo, Andrea Mara
dc.date.accessioned2012-11-12T18:12:21Z
dc.date.available2012-11-12T18:12:21Z
dc.date.issued2010
dc.identifier.citationRODRIGUES, Claudiney Melquıades et al. (2010) Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection. PLoS Negl Trop Dis 4(10): e846
dc.identifier.issn19352727
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/5792
dc.description.sponsorshipPRONEX; FAPEMIG (WWW.fapemig.br); CNPq (www.cnpq.br) and CAPEs (www.capes.gov.br).
dc.language.isoeng
dc.rightsopen access
dc.titleCoinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection
dc.typeArticle
dc.identifier.doi10.1371/journal.pntd.0000846
dc.description.abstractenA century after the discovery of Trypanosoma cruzi in a child living in Lassance, Minas Gerais, Brazil in 1909, many uncertainties remain with respect to factors determining the pathogenesis of Chagas disease (CD). Herein, we simultaneously investigate the contribution of both host and parasite factors during acute phase of infection in BALB/c mice infected with the JG and/or CL Brener T. cruzi strains. JG single infected mice presented reduced parasitemia and heart parasitism, no mortality, levels of pro-inflammatory mediators (TNF-a, CCL2, IL-6 and IFN-c) similar to those found among naı¨ve animals and no clinical manifestations of disease. On the other hand, CL Brener single infected mice presented higher parasitemia and heart parasitism, as well as an increased systemic release of pro-inflammatory mediators and higher mortality probably due to a toxic shock-like systemic inflammatory response. Interestingly, coinfection with JG and CL Brener strains resulted in intermediate parasitemia, heart parasitism and mortality. This was accompanied by an increase in the systemic release of IL-10 with a parallel increase in the number of MAC-3+ and CD4+ T spleen cells expressing IL-10.Therefore, the endogenous production of IL-10 elicited by coinfection seems to be crucial to counterregulate the potentially lethal effects triggered by systemic release of pro-inflammatory mediators induced by CL Brener single infection. In conclusion, our results suggest that the composition of the infecting parasite population plays a role in the host response to T. cruzi in determining the severity of the disease in experimentally infected BALB/c mice. The combination of JG and CL Brener was able to trigger both protective inflammatory immunity and regulatory immune mechanisms that attenuate damage caused by inflammation and disease severity in BALB/c mice.
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunopatologia, Ouro Preto, MG, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
dc.creator.affilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
dc.subject.enTrypanosoma cruzi
Appears in Collections:MG - IRR - Artigos de Periódicos

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