Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/5815
Title: Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines
Authors: Oliveira, Viviane Sampaio Boaventura de
Santos, Claire da Silva
Cardoso, Cristina Ribeiro de Barros
Andrade, José de
dosSantos, Washington Luis Conrado
Clarêncio, Jorge
Silva, João Santana da
Borges, Valeria de Matos
Barral Netto, Manoel
Brodskyn, Claudia Ida
Barral, Aldina Maria Prado
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal do Triângulo Mineiro.Departamento de Ciências Biológicas. Minas Gerais, BH, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Mucosal leishmaniasis (ML) is characterised by severe tissue destruction. Herein, we evaluated the involvement of the IL-17-type response in the inflammatory infiltrate of biopsy specimens from 17 ML patients. IL-17 and IL-17-inducing cytokines (IL-1ß, IL-23, IL-6 and TGF-ß) were detected by immunohistochemistry in ML patients. IL-17(+) cells exhibited CD4(+), CD8(+) or CD14(+) phenotypes, and numerous IL-17(+) cells co-expressed the CC chemokine receptor 6 (CCR6). Neutrophils, a hallmark of Th17-mediated inflammation, were regularly detected in necrotic and perinecrotic areas and stained positive for neutrophil elastase, myeloperoxidase and MMP-9. Taken together, these observations demonstrate the existence of Th17 cells in ML lesions associated with neutrophils in areas of tissue injury and suggest that IL-17 is involved in ML pathogenesis
Keywords: Human
Mucosal leishmaniasis
Neutrophils
Th17
DeCS: Interleucina-17/Imunologia
Leishmania/Imunologia
Leishmaniose Mucocutânea/Imunologia
Neutrófilos/Imunologia
Issue Date: 2010
Citation: BOAVENTURA, V. S. et al. Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. European Journal of Immunology, v. 40, n. 10, p. 2830-2836, out. 2010.
DOI: 10.1002/eji.200940115
ISSN: 0014-2980
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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