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HUMAN MUCOSAL LEISHMANIASIS: NEUTROPHILS INFILTRATE AREAS OF TISSUE DAMAGE THAT EXPRESS HIGH LEVELS OF TH17-RELATED CYTOKINES
Leishmania/Imunologia
Leishmaniose Mucocutânea/Imunologia
Neutrófilos/Imunologia
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Abstract
Mucosal leishmaniasis (ML) is characterised by severe tissue destruction. Herein, we evaluated the involvement of the IL-17-type response in the inflammatory infiltrate of biopsy specimens from 17 ML patients. IL-17 and IL-17-inducing cytokines (IL-1ß, IL-23, IL-6 and TGF-ß) were detected by immunohistochemistry in ML patients. IL-17(+) cells exhibited CD4(+), CD8(+) or CD14(+) phenotypes, and numerous IL-17(+) cells co-expressed the CC chemokine receptor 6 (CCR6). Neutrophils, a hallmark of Th17-mediated inflammation, were regularly detected in necrotic and perinecrotic areas and stained positive for neutrophil elastase, myeloperoxidase and MMP-9. Taken together, these observations demonstrate the existence of Th17 cells in ML lesions associated with neutrophils in areas of tissue injury and suggest that IL-17 is involved in ML pathogenesis
DeCS
Interleucina-17/ImunologiaLeishmania/Imunologia
Leishmaniose Mucocutânea/Imunologia
Neutrófilos/Imunologia
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