| Author | Luz, Paula M. | |
| Author | Deshpande, Vijeta | |
| Author | Kazemian, Pooyan | |
| Author | Scott, Justine A. | |
| Author | Shebl, Fatma M. | |
| Author | Spaeth, Hailey | |
| Author | Pimenta, Cristina | |
| Author | Stern, Madeline | |
| Author | Pereira, Gerson | |
| Author | Struchiner, Claudio J. | |
| Author | Grinsztejn, Beatriz | |
| Author | Veloso, Valdiléa G. | |
| Author | Freedberg, Kenneth A. | |
| Access date | 2023-08-02T20:36:23Z | |
| Available date | 2023-08-02T20:36:23Z | |
| Document date | 2023 | |
| Citation | LUZ, Paula M. et al. Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study. BMC Public Health, v. 23, n. 1, p. 1-12, June 2023. | en_US |
| ISSN | 1471-2458 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59885 | |
| Sponsorship | This work was supported by the National Institute of Allergy and Infectious Diseases (R37 AI058736) and by the Department of Chronic Conditions and Sexually Transmitted Infections (DCCI) of the Ministry of Health of Brazil. This project was also made possible thanks to Unitaid’s funding and support. Unitaid accelerates access to innovative health products and lays the foundations for scale up by countries and partners. Unitaid is a hosted partnership of WHO. PML, BG, and CJS acknowledge funding from the National Council of Technological and Scientifc Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). The content is solely the responsibility of the authors and does not necessarily represent the ofcial views of the National Institute of Health or other funders. | en_US |
| Language | eng | en_US |
| Publisher | BioMed Central | en_US |
| Rights | open access | en_US |
| Title | Impact of pre-exposure prophylaxis uptake among gay, bisexual, and other men who have sex with men in urban centers in Brazil: a modeling study | en_US |
| Type | Article | en_US |
| DOI | 10.1186/s12889-023-15994-0 | |
| Abstract | Background: Men who have sex with men (MSM) in Brazil remain disproportionately affected by HIV. We estimated the potential incidence reduction by five years with increased uptake of publicly-funded, daily, oral tenofovir/emtricitabine (TDF/FTC) for HIV pre-exposure prophylaxis (PrEP) among MSM using the Cost Effectiveness of Preventing AIDS Complications microsimulation model. We used national data, local studies, and literature to inform model parameters for three cities: Rio de Janeiro, Salvador, and Manaus. Results: In Rio de Janero, a PrEP intervention achieving 10% uptake within 60 months would decrease incidence by 2.3% whereas achieving 60% uptake within 24 months would decrease incidence by 29.7%; results were similar for Salvador and Manaus. In sensitivity analyses, decreasing mean age at PrEP initiation from 33 to 21 years increased incidence reduction by 34%; a discontinuation rate of 25% per year decreased it by 12%. Conclusion: Targeting PrEP to young MSM and minimizing discontinuation could substantially increase PrEP's impact. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA. | en_US |
| Affilliation | Department of Operations. Weatherhead School of Management. Case Western Reserve University. Cleveland, OH, USA. | en_US |
| Affilliation | Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA. | en_US |
| Affilliation | Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA. | en_US |
| Affilliation | Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA. | en_US |
| Affilliation | Ministry of Health of Brazil. Brasília, DF, Brazil. | en_US |
| Affilliation | Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA. | en_US |
| Affilliation | Ministry of Health of Brazil. Brasília, DF, Brazil. | en_US |
| Affilliation | Fundação Getúlio Vargas. Escola de Matemática Aplicada. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Medical Practice Evaluation Center. Massachusetts General Hospital. Boston, MA, USA / Harvard University Center for AIDS Research. Harvard Medical School. Cambridge, MA, USA / Division of General Internal Medicine. Massachusetts General Hospital. Boston, MA, USA / Division of Infectious Diseases. Massachusetts General Hospital. Boston, MA, USA / Department of Health Policy and Management. Harvard School of Public Health. Boston, MA, USA. | en_US |
| Subject | Pre-exposure prophylaxis (PrEP) | en_US |
| Subject | HIV prevention | en_US |
| Subject | Men who have sex with men | en_US |
| Subject | Modeling | en_US |
| Subject | Latin America and the Caribbean | en_US |
| Subject | Key and vulnerable populations | en_US |
| e-ISSN | 1471-2458 | |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
