| Author | Santos, Karina dos | |
| Author | Rosado, Eliane Lopes | |
| Author | Fonseca, Ana Carolina Proença da | |
| Author | Belfort, Gabriella Pinto | |
| Author | Silva, Letícia Barbosa Gabriel da | |
| Author | Ribeiro-Alves, Marcelo | |
| Author | Zembrzuski, Verônica Marques | |
| Author | Campos Jr., Mario | |
| Author | Zajdenverg, Lenita | |
| Author | Drehmer, Michele | |
| Author | Martínez, J. Alfredo | |
| Author | Saunders, Cláudia | |
| Access date | 2023-08-26T16:06:45Z | |
| Available date | 2023-08-26T16:06:45Z | |
| Document date | 2023 | |
| Citation | SANTOS, Karina dos et al. A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus. Life (Basel), v. 13, n. 5, p. 1-17, Apr. 2023. | en_US |
| ISSN | 2075-1729 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60240 | |
| Description | Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Maternidade Escola da UFRJ (CAAE–46913115.0.0000.5275; 15 July 2015). The study was registered in the Brazilian Registry of Clinical Trials (RBR-4tbgv6). Informed Consent Statement: Written informed consent was obtained from the patient(s) to publish this paper. Data Availability Statement: Please, contact the correspondent author to verify the availability of the research data. Acknowledgments: Thanks to Marcus Miranda, Karina Bilda de Castro Rezende, Rita Bornia, Joffre Amin, Jr., and Jorge Rezende Filho for their support during the study. | en_US |
| Sponsorship | This research received financial support from: National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico–CNPq-Brazil), grant number: 409032/2016-6; Carlos Chagas Filho Foundation to Research in the State of Rio de Janeiro (Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro—FAPERJBrazil), grant numbers: E-26/202.972/2016-6 and E-26/201.193/2021; and Coordination for the Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–CAPES-Brazil), Finance Code 001. | en_US |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | |
| Title | A Pilot Study of Dietetic, Phenotypic, and Genotypic Features Influencing Hypertensive Disorders of Pregnancy in Women with Pregestational Diabetes Mellitus | en_US |
| Type | Article | |
| DOI | 10.3390/life13051104 | |
| Abstract | Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and perinatal morbimortality. Dietetic, phenotypic, and genotypic factors influencing HDP were analyzed during a nutrigenetic trial in Rio de Janeiro, Brazil (2016-2020). Pregnant women with pregestational diabetes mellitus (n = 70) were randomly assigned to a traditional or DASH diet group. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured during prenatal visits and HDP were diagnosed using international criteria. Phenotypic data were obtained from medical records and personal interviews. Genotyping for FTO and ADRB2 polymorphisms used RT-PCR. Linear mixed-effect models and time-to-event analyses were performed. The variables with significant effect on the risk for progression to HDP were: black skin color (adjusted hazard ratio [aHR] 8.63, p = 0.01), preeclampsia in previous pregnancy (aHR 11.66, p < 0.01), SBP ≥ 114 mmHg in the third trimester (aHR 5.56, p 0.04), DBP ≥ 70 mmHg in the first trimester (aHR 70.15, p = 0.03), mean blood pressure > 100 mmHg (aHR 18.42, p = 0.03), and HbA1c ≥ 6.41% in the third trimester (aHR 4.76, p = 0.03). Dietetic and genotypic features had no significant effect on the outcome, although there was limited statistical power to test both. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil / Universidade Federal do Estado do Rio de Janeiro. Escola de Nutrição. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil / Universidade Federal do Estado do Rio de Janeiro. Escola de Nutrição. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Departamento de Clínica Médica. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Programa de Pós-Graduação em Epidemiologia. Programa de Pós-Graduação em Alimentação, Nutrição e Saúde. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Precision Nutrition and Cardiometabolic Health Program. IMDEA Food Institute (Instituto Madrileño de Estudos Avanzados en Alimentación). Crta. de Canto Blanco, Madrid, Spain. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro. Programa de Pós-Graduação em Nutrição. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | DASH diet | en_US |
| Subject | Nutrigenetics | en_US |
| Subject | Preeclampsia | en_US |
| Subject | Pregnancy in diabetes | en_US |
| Subject | Pregnancy-induced hypertension | en_US |
| e-ISSN | 2075-1729 | |
