| Author | Patriota, Yuri Basilio Gomes | |
| Author | Arruda, Igor Eduardo Silva | |
| Author | Oliveira, Antônia Carla de Jesus | |
| Author | Oliveira, Thaisa Cardoso de | |
| Author | Silva, Eliadna de Lemos Vasconcelos | |
| Author | Chaves, Luíse Lopes | |
| Author | Ribeiro, Fábio de Oliveira Silva | |
| Author | Silva, Durcilene Alves da | |
| Author | Soares, Mônica Felts de La Roca | |
| Author | Soares-Sobrinho, José Lamartine | |
| Access date | 2023-12-12T14:05:50Z | |
| Available date | 2023-12-12T14:05:50Z | |
| Document date | 2021 | |
| Citation | PATRIOTA, Yuri Basilio Gomes et al. Synthesis of Eudragit® L100-coated chitosan-based nanoparticles for oral enoxaparin delivery. International Journal Of Biological Macromolecules, [S.l.], v. 193, p. 450-456, dez. 2021. | en_US |
| ISSN | 1879-0003 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/61718 | |
| Language | por | en_US |
| Rights | restricted access | |
| MeSH | Chitosan / chemistry* | en_US |
| MeSH | Drug Carriers / chemistry* | en_US |
| MeSH | Drug Liberation | en_US |
| MeSH | Enoxaparin / chemistry* | en_US |
| MeSH | Nanoparticles / chemistry* | en_US |
| MeSH | Particle Size | en_US |
| Title | Synthesis of Eudragit® L100-coated chitosan-based nanoparticles for oral enoxaparin delivery | en_US |
| Type | Article | |
| DOI | 10.1016/j.ijbiomac.2021.10.111 | |
| Abstract | Enoxaparin is an effective biological molecule for prevention and treatment of coagulation disorders. However, it is poorly absorbed in the gastrointestinal tract. In this study, we developed an Eudragit® L100 coated chitosan core shell nanoparticles for enoxaparin oral delivery (Eud/CS/Enox NPs) through a completely eco-friendly method without employing any high-energy homogenizer technique and any organic solvents. Spherical nanocarriers were successfully prepared with particle size lower than 300 nm, polydispersity index about 0.12 and zeta potential higher than +25 mV, entrapment efficiency greater than 95% and the in vitro release behavior confirms the good colloidal stability and the successful Eudragit® L100 coating process demonstrated by negligible cumulative enoxaparin release (<10%) when the particles are submitted to simulated gastric fluid conditions. Finally, we demonstrated that the core-shell structure of the particle influenced the drug release mechanism of the formulations, indicating the presence of the Eudragit® L100 on the surface of the particles. These results suggested that enteric-coating approach and drug delivery nanotechnology can be successfully explored as potential tools for oral delivery of enoxaparin. | en_US |
| Affilliation | Federal University of Pernambuco. Quality Control Core of Medicines and Correlates. Recife, PE, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Immunology. Recife, PE, Brazil. | en_US |
| Affilliation | Federal University of Delta of Parnaiba. Federal University of Delta of Parnaiba. Parnaiba, PI, Brazil. | en_US |
| Affilliation | Federal University of Pernambuco. Quality Control Core of Medicines and Correlates. Recife, PE, Brazil. | en_US |
| Subject | Biomacromolecule | en_US |
| Subject | Chitosan | en_US |
| Subject | Drug delivery system | en_US |
| Subject | Eudragit® L100 | en_US |
| Subject | Low-molecular weight heparin | en_US |
| Subject | Polymer nanoparticles | en_US |
| e-ISSN | 1879-0003 | |
