Objectives: Mitigating the socioeconomic determinants of Tuberculosis(TB) and systematic screening of contacts and high-riskgroups are targets of The World Health Organization (WHO)End TB Strategy by 2035. Our aim was to link socioeconomicinformation to TB datasets to inform policy makers in Braziland contribute to addressing current challenges. Approach: Following a signed technical cooperation agreement with theMinistry of Health (MoH), we linked nationwide data on1.405.682 registries of TB diagnosed between 2004 and 2019in Brazil to 131.697.800 demographic and socioeconomic reg-istries from the 100 Million Brazilian Cohort (2001-2018) pre-viously linked to nationwide mortality data. We establishedclose links with TB managers to understand the database,clean and deduplicate registries and to analyse the data. Wetook advantage of the data structure, to set up a cohort ofhousehold contacts of TB patients and produce estimates ofTB incidence by subgroups of demographic and socioeconomiccharacteristics. Results: The interaction of the MoH was effective and facilitated bya robust TB Programme in the country. 567.999 (40,41%)TB cases were linked to the 100 Million Brazilian Cohort withhigh specificity (93.6%) and sensitivity (94.6%). Using familyidentifiers, we established the first TB case within a family unit(i.e., primary case) and followed their household contacts up to15 years. We found the TB incidence among household con-tacts to be 427.8/100.000 person-years (95%CI 419.1-436.8).In the first year following the identification of the primary case,there was higher cumulative incidence among household con-tacts under 5 years of age, which was followed by a plateau ofcases in this age group. Cummulative incidence in the otherage groups presented a constant increase over time. Conclusion: The close collaboration with the MoH, the development of aneffective linkage algorithm and the availability of large socioe-conomic data allowed for a unique analysis of the high inci-dence of TB among household contacts. Findings reinforceneed for constant dialogue among stakeholders to strengthencase detection by primary health care.