Introduction: Schistosomiasis is an important public health problem closely related to poverty, lack of health and sanitation services. Individuals susceptible to infection by geohelminths associated with S. mansoni, may show changes in the blood count. The objective of the present work is to evaluate the alterations in the hematological parameters in individuals positive for S. mansoni and co-infected by geohelminths. Methodology: This is a cross-sectional study with 321 residents of three villages in the rural area of the municipality of Conde-Ba, Brazil, who provided whole blood and stool samples for the Hemogram and Kato-Katz. Results: 56.07% (n=180) of the samples were positive for S. mansoni, 40.19% (n=129) for A. lumbricoides and 52.96% (n=170) for T. trichiura. We evaluated the blood count of individuals infected with only one helminth. Individuals positive for S. mansoni had a higher number of red blood cells (p=0.0392) compared to the negatives. A. lumbricoides positive individuals had higher eosinophil counts than negative individuals (p=0.0347). We also evaluated changes in blood count among uninfected individuals (G0), infected only by S. mansoni (G1), by S. mansoni and another helminth (G2), and by S. mansoni and two more (G3). G1 had a higher number of red blood cells when compared to G3 (p=0.0063). G1 individuals had a higher hemoglobin concentration when compared to G2 and G3 (p=0.0006), as well as a higher percentage of hematocrit when compared to G3 (p=0.0020). As for total leukocytes, G2 individuals had a higher count when compared to G1 (p=0.0034). Related to eosinophils, individuals G0 and G1 had lower eosinophil counts when compared to G2 and G3 (p=0.0001). Finally, we evaluated the correlation between blood count and parasite burden of helminths. A negative correlation was observed for hemoglobin (p=0.0466; r=-0.5830) and a positive correlation for leukocyte count (p=0.1517; r=0.4406), eosinophils (p=0.0040; r=0.7622) and platelets (p=0.0301; r=0.6242) for A. lumbricoides. A positive correlation was also observed for platelet count (p=0.0223; r=0.4303) for T. trichiura. Conclusion: Individuals infected only by S. mansoni did not show significant changes in the blood count. We did not observe a correlation between their parasite load and the results of the blood count, with the exception of the red blood cell count, which was higher in infected individuals. Changes in the blood count become accentuated when co-infection is observed between individuals with more than one species of geohelminth associated with S. mansoni.