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DENGUE VIRUS SEROTYPE 1 EFFECTS ON MOSQUITO SURVIVAL DIFFER AMONG GEOGRAPHICALLY DISTINCT AEDES AEGYPTI POPULATIONS
Keirsebelik, Milan Sinne Gustaaf et al. | Date Issued: 2024
Author
Keirsebelik, Milan Sinne Gustaaf
David, Mariana Rocha
Pavan, Márcio Galvão
Lima, Dinair Couto
Palomino, Miriam
Rahman, Rafi Ur
Hoffmann, Ary A.
Bahia, Ana Cristina
Caljon, Guy
Freitas, Rafael Maciel de
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil / University of Antwerp. Laboratory of Microbiology, Parasitology and Hygiene. Wilrijk-Antwerp, Belgium / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Salud. Centro Nacional de Salud Pública. Laboratorio de Referência Nacional de Entomologia. Lima, Peru.
Commission on Science and Technology for Sustainable Development in the South (COMSATS) University. Department of Biosciences. Islamabad, Pakistan.
The University of Melbourne. School of BioSciences. Bio21 Institute. Pest and Environmental Adaptation Research Group. Melbourne, Australia.
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Programa Temático de Biologia Molecular e Estrutural. Laboratório de Bioquímica de Insetos e Parasitos. Rio de Janeiro, RJ, Brasil.
University of Antwerp. Laboratory of Microbiology, Parasitology and Hygiene. Wilrijk-Antwerp, Belgium.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil / Bernhard Nocht Institute for Tropical Medicine. Hamburg, Germany.
Abstract
The mosquito Aedes aegypti is distributed worldwide and is recognized as the primary vector for dengue in numerous countries. To investigate whether the fitness cost of a single DENV-1 isolate varies among populations, we selected four Ae. aegypti populations from distinct localities: Australia (AUS), Brazil (BRA), Pakistan (PAK), and Peru (PER). Utilizing simple methodologies, we concurrently assessed survival rates and fecundity. Overall, DENV-1 infection led to a significant decrease in mosquito survival rates, with the exception of the PER population. Furthermore, infected Ae. aegypti from PAK, the population with the lowest infection rate among those tested, exhibited a noteworthy reduction in egg laying. These findings collectively suggest that local mosquito-virus adaptations may influence dengue transmission in endemic settings.
Keywords
Aedes aegypti
Vectorial capacity
Dengue
Mosquito-virus interaction
Survival
Fecundity
Vector competence
 
Publisher
MDPI
Citation
KEIRSEBELIK, Milan Sinne Gustaaf et al. Dengue virus serotype 1 effects on mosquito survival differ among geographically distinct Aedes aegypti populations. Insects, v. 15, n. 6, p. 1-13, 28 May 2024.
DOI
10.3390/insects15060393
ISSN
2075-4450
Notes
Produção científica do Laboratório de Mosquitos Transmissores de Hematozoários.
Simple Summary: The Aedes aegypti mosquito is distributed throughout several tropical countries and is considered one of the most important species vectoring arboviruses such as dengue. It has been debated whether local adaptations affect mosquito vectorial capacity. In this study, we used a network of collaborators to access Ae. aegypti mosquitoes from four different countries: Australia (AUS), Brazil (BRA), Pakistan (PAK), and Peru (PER). For each population, we generated a DENV-exposed group and an unexposed control and estimated survival rate and fecundity as a consequence of DENV-1 infection. Overall, DENV-1 infection reduced mosquito survival rates, but this effect was not observed in PER Ae. aegypti females. The number of eggs laid by Ae. aegypti females was similar among tested populations, with the exception of PAK in which DENV-infected mosquitoes laid fewer eggs than the uninfected control. Taken together, our results suggest geographic variation among mosquitoes that could impact dengue transmission patterns across natural settings.