Please use this identifier to cite or link to this item:
Type
Papers presented at eventsCopyright
Open access
Sustainable Development Goals
03 Saúde e Bem-EstarCollections
Metadata
Show full item record
DIAGNOSIS OF TRYPANOSOMA CRUZI AND LEISHMANIA SP INFECTIONS IN DOGS IN A CITY WHERE CHAGAS DISEASE AND VISCERAL LEISHMANIASIS ARE COENDEMIC
Leishmaniose
Antígenos quiméricos
Animais sentinela
Sobreposição de infecção
Author
Affilliation
Abstract
Chagas disease (CD) and visceral leishmaniasis (VL) are neglected tropical diseases caused by trypanosomatids. They are endemic in Brazil and overlap in some areas. In the present study, we investigated the presence of anti-T. cruzi and anti-Leishmania antibodies in dogs living in Tremedal-BA, where both diseases coexist. A total of 17 samples were included in the study, 16 from dogs living in urban and one from rural settings (47 km from the urban area). All sera were tested for Chagas disease using latent class analysis (LCA) as the reference test. Four T. cruzi-chimeric antigens (IBMP-8.1, -8.2, -8.3, and -8.4) were used as latent variables for LCA. According to LCA, T. cruzi antibodies were detected in one dog (5.9%; a posteriori probability of 94.9%). Regarding VL, all samples were first tested with the DPP® Bio-Manguinhos rapid test and seven samples were considered positive (41.2%). Subsequently, all samples were subjected to a confirmatory diagnosis, but only one sample remained positive for leishmaniasis. The positivity for CD and leishmaniasis involved the same dog living in the rural area of Tremedal. Our results suggest that the DPP test should be used only as a serological screening test, considering the elevated rate of false positive results. In addition, the presence of animals with anti-T. cruzi and anti-Leishmania sp antibodies suggests an active transmission cycle of these parasites in the region. Therefore, epidemiological surveillance measures should be considered to avoid human transmission.
Keywords in Portuguese
Doença de chagasLeishmaniose
Antígenos quiméricos
Animais sentinela
Sobreposição de infecção
Share