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ROLE OF TUMOR NECROSIS FACTOR–α AND INTERLEUKIN-10 PROMOTER GENE POLYMORPHISMS IN LEPROSY
Santos, Adalberto Rezende et al. | Date Issued: 2002
Author
Santos, Adalberto Rezende
Suffys, Philip Noel
Vanderborght, Patrícia Rosa
Moraes, Milton Ozório
Vieira, Leila Maria Machado
Cabello Acero, Pedro Hernan
Bakker, Aleida M.
Matos, Haroldo José de
Huizinga, Tom W. J.
Ottenhoff, Tom H. M.
Sampaio, Elizabeth Pereira
Sarno, Euzenir Nunes
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
Leiden University Medical Center. Rheumatology. Leiden, The Netherlands.
Universidade do Estado do Rio de Janeiro. Centro Biomédico. Faculdade de Ciências Médicas. Laboratório de Informática Médica. Rio de Janeiro, RJ, Brasil.
Leiden University Medical Center. Rheumatology. Leiden, The Netherlands.
Leiden University Medical Center. Immunohematology and Blood Transfusion. Leiden, The Netherlands.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Abstract
Single-nucleotide polymorphisms within the genes coding for tumor necrosis factor (TNF)–α and interleukin (IL)–10 have been associated with several infectious diseases. To determine whether such polymorphisms are associated with leprosy, genotyping was performed at the −308 and −238 positions of the promoter of the TNF-α gene in 210 and 191 patients with multibacillary (MB) leprosy, respectively; 90 and 79 patients with paucibacillary (PB) leprosy; and 92 control subjects. For the −592 and −819 positions within the promoter of the IL-10 gene, 143 patients with MB leprosy, 79 patients with PB leprosy, and 62 control subjects were included in the analysis. TNF2 allele frequency was significantly higher among control subjects than among all patients with leprosy or in the MB group (P<.05 and P<.01). For the IL-10 gene, the frequency of the homozygous −819TT genotype was significantly higher among patients than among control subjects. These data indicate that a relationship exists between TNF-α and IL-10 promoter polymorphisms and the development of PB leprosy.
Keywords
Tumor necrosis factors
Polymorphism
Communicable diseases
Gene frequency
Genes
Genotype
Homozygote
Interleukin-10
Interleukins
Leprosy
Single nucleotide polymorphism
Genotype determination
Paucibacillary
 
Publisher
Oxford University Press
Citation
SANTOS, Adalberto Rezende et al. Role of tumor necrosis factor–α and interleukin-10 promoter gene polymorphisms in leprosy. The Journal of Infectious Diseases, v. 186, n. 11, p. 1687-1691, 1 Dec. 2002.
DOI
10.1086/345366
ISSN
0022-1899
Notes
Produção científica do Laboratório de Biologia Molecular e Doenças Endêmicas.
Produção científica do Laboratório de Genética Humana.
Produção científica do Laboratório de Hanseníase.