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TRACING THE EVOLUTION OF THE CHIKUNGUNYA VIRUS IN ARGENTINA, 2016-2023: INDEPENDENT INTRODUCTIONS AND PROMINENCE OF LATIN AMERICAN LINEAGES.
Fabbri, Cintia et al. | Fecha del documento: 2024
Autor
Fabbri, Cintia
Giovanetti, Marta
Luppo, Victoria
Fonseca, Vagner
Garcia, Jorge
Barulli, Cintia
Feroci, Mariel
Perrone, Sofia
Casoni, Doraldina
Giamperetti, Sergio
Lopez, Maria Cristina Alvarez
Foussal, Maria Delia
Figueredo, Mauricio
Salvatierra, Karina
Lejona, Sergio
Diaz, Natalia Ruiz
Castro, Gonzalo
Bravo, Gabriela
Jackel, Noelia
Sen, Carina
Caride, Tomás Poklepovich
Franco, Leticia
Giovachini, Carlos
Rico, Jairo Mendez
Alcantara, Luiz Carlos Junior
Morales, Maria Alejandra
Afiliación
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Department of Sciences and Technologies for Sustainable Development and One Health. Universita Campus Bio-Medico di Roma. Rome, Italy/Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte,MG, Brazil/Climate Amplified Diseases and Epidemics. Belo Horizonte, MG, Brazil.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Climate Amplified Diseases and Epidemics. Belo Horizonte, MG, Brazil/Universidade do Estado da Bahia. Departamento de Ciências Exatas e da Terra. Salvador, BA, Brazil.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Hospital de Infecciosas Francisco Javier Muñiz. CABA, Buenos Aires, Argentina.
Hospital General de Niños R. Gutiérrez. CABA, Buenos Aires, Argentina.
Hospital Julio C. Perrando. Chaco, Argentina.
Hospital de Alta Complejidad "Pte. Juan Domingo Perón", Formosa, Argentina.
Laboratorio de Alta Complejidad de Posadas. Misiones, Argentina.
CEMAR. Secretaria de Salud. Municipalidad de Rosario, Santa Fe, Argentina.
Laboratorio Central de Redes y Programas de Corrientes. Corrientes, Argentina.
Laboratorio Central de la Provincia de Cordoba. Córdoba, Argentina.
Hospital Señor del Milagro. Salta, Argentina.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Unidad Operativa. Centro Nacional de Genómica y Bioinformática. ANLIS.
Infectious Hazards Management. Health Emergencies Department. Pan American Health Organization/World Health Organization. Washington, DC, USA.
Direccion de Epidemiologia. Minsiterio de Salud de la Nacion. Buenos Aires, Argentina.
Infectious Hazards Management. Health Emergencies Department. Pan American Health Organi-zation/World Health Organization. Washington, DC, USA.
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte,MG, Brazil/Climate Amplified Diseases and Epidemics. Belo Horizonte, MG, Brazil.
Instituto Nacional de Enfermedaes Virales Humanas "Dr. Maiztegui". ANLIS, Pergamino, Argentina.
Resumen en ingles
Chikungunya virus (CHIKV) has emerged as a significant public health concern due to its rapid spread and potential for causing debilitating epidemics. In Argentina, the virus has garnered attention since its introduction to the Americas in 2013, due to its growing incidence and impact in neighbouring countries. Here we present a comprehensive analysis of the spatiotemporal dynamics of CHIKV in Argentina, focusing on the evolutionary trajectory of its genetic variants. Through a combination of active surveillance, screening of historical and recent samples, and whole-genome sequencing, we traced the evolutionary history of CHIKV lineages circulating within the country. Our results reveal that two distinct genotypes circulated in Argentina: The Asian lineage during the 2016 epidemic and the ECSA lineage in 2023. This distribution reflects the dominance of particular variants across Latin America. Since 2023, the ECSA lineage has led to a surge in cases throughout the Americas, marking a significant shift. The replacement of lineages in the American region constitutes a major epidemiological event, potentially affecting the dynamics of virus transmission and the clinical outcomes in impacted populations. The spatiotemporal analysis highlights CHIKV's distribution across Argentina and underscores the significant role of human mobility, especially when considering recent epidemics in neighbouring countries such as Paraguay and Uruguay, which have facilitated the spread and introduction of the viral strain into different districts. By integrating epidemiological data with genomic insights, we elucidate the patterns of virus dissemination, highlighting key areas of transmission and potential factors contributing to its spread.
Palabras clave en ingles
Argentina
CHIKV
evolution
genomic surveillance
molecular epidemiology
phylodynamic
 
Editor
Taylor & Francis
Referencia
FABBRI, Cíntia et al. Tracing the Evolution of the Chikungunya Virus in Argentina, 2016-2023: Independent Introductions and prominence of Latin American Lineages. Emerg Microbes Infect, v. 13, n. 1, 2362941, 2024. doi.org/10.1080/22221751.2024.2362941.
ISSN
2222-1751