| Author | Albuquerque, Andre Gustavo Neves de | |
| Author | Moraes, Maria Elisa | |
| Author | Vanderborght, Patrícia Rosa | |
| Author | Romero, Matilde | |
| Author | Santos, Adalberto Rezende | |
| Author | Moraes, Milton Ozório | |
| Author | Moraes, José Roberto Feresin | |
| Access date | 2024-08-27T16:37:23Z | |
| Available date | 2024-08-27T16:37:23Z | |
| Document date | 2004 | |
| Citation | ALBUQUERQUE, Andre Gustavo Neves de et al. Tumor necrosis factor and interleukin-10 gene promoter polymorphisms in brazilian population and in Terena indians. Transplantation Proceedings, v. 36, n. 4, p. 825-826, May 2004. | |
| ISSN | 0041-1345 | |
| URI | https://www.arca.fiocruz.br/handle/icict/65604 | |
| Description | Produção científica do Laboratório de Hanseníase. | pt_BR |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Title | Tumor necrosis factor and interleukin-10 gene promoter polymorphisms in brazilian population and in Terena indians | en_US |
| Type | Article | |
| DOI | 10.1016/j.transproceed.2004.03.080 | |
| Abstract | The Terena Amerindians are located in the midwestern region of Brazil. We have previously reported a restricted polymorphism for HLA class I and class II in 99 unrelated Terena using PCR-SSO and more recently for MICA. There are single nucleotide polymorphisms (SNPs) that determine high or low production of certain cytokines. We have now studied the frequencies of mutant allele (A) at position −308 in the promoter of the gene tumor necrosis factor (TNF)-α (pro-inflammatory cytokine) and the alleles A and T, at position −1082 and −819, respectively, in the promoter of the interleukin (IL)-10 gene, in 51 of these subjects from the Terena tribe using PCR SSP and in 195 normal unrelated healthy Brazilians using PCR-RLFP. All 51 Terena Indians tested (100%) had the G/G genotype at position TNF-α −308, with no mutation found thus far. In contrast, among the Brazilian general population, the allelic frequency of A was 18.9%. When anti-inflammatory cytokine IL-10 was studied at two different positions, −1082 and −819, a high mutation rate was found when Terena were compared with the general Brazilian population (P < .05). The genetic cytokine profile may be required to balance the restricted HLA repertoire for peptide presentation in this native population. | en_US |
| Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Instituto de Biologia Roberto Alcantara Gomes. Laboratório de Imunogenética. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | JRM Investigações Imunológicas. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | JRM Investigações Imunológicas. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Instituto de Biologia Roberto Alcantara Gomes. Laboratório de Imunogenética. Rio de Janeiro, RJ, Brasil / JRM Investigações Imunológicas. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Subject | Terena Amerindians | en_US |
| Subject | HLA polymorphism | en_US |
| Subject | Cytokine genetics | en_US |
| Subject | Genetic adaptation | en_US |
| e-ISSN | 1873-2623 | |
