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NEUROLOGICAL DISEASE IN HIV-INFECTED PATIENTS IN THE ERA OF HIGHLY ACTIVE ANTIRETROVIRAL TREATMENT: A BRAZILIAN EXPERIENCE
SIDA
Doença neurológica
Terapia anti-retroviral altamente ativa
Brasil
Alternative title
Doença neurológica em pacientes infectados pelo HIV na era da terapia anti-retroviral altamente ativa: uma experiência brasileiraAuthor
Affilliation
Minas Gerais Hospital State Foundation. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. School of Medicine. Infectious Disease Service. Belo Horizonte, MG.
Oswaldo Cruz Foundation. René Rachou Research Center. Belo Horizonte, MG, Brazil.
Minas Gerais Hospital State Foundation . Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. School of Medicine. Department of Preventive and Social Medicine. Belo Horizonte, MG, Brazil
Oswaldo Cruz Foundation. René Rachou Research Center. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. School of Medicine. Infectious Disease Service. Belo Horizonte, MG.
Oswaldo Cruz Foundation. René Rachou Research Center. Belo Horizonte, MG, Brazil.
Minas Gerais Hospital State Foundation . Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil.
Federal University of Minas Gerais. School of Medicine. Department of Preventive and Social Medicine. Belo Horizonte, MG, Brazil
Oswaldo Cruz Foundation. René Rachou Research Center. Belo Horizonte, MG, Brazil.
Abstract in Portuguese
Com o objetivo de estudar as doenças neurológicas em pacientes HIV/AIDS e sua relação com a terapia anti-retroviral altamente ativa, foi realizado estudo transversal em hospital público de doenças infecciosas de Belo Horizonte, Brasil, no período de fevereiro de 1999 a março de 2000. Doença neurológica foi observada em 194 (46,5%) dos 417 indivíduos incluídos e um novo episódio de doença neurológica definidora de AIDS ocorreu em 23,7% pacientes. Toxoplasmose (42,3%), criptococose (12,9%) e tuberculose (10,8%) foram as principais causas de complicações neurológicas. A maioria dos pacientes estava em uso de terapia anti-retroviral altamente ativa (79,3%) e esses indivíduos apresentaram maiores contagens de linfócitos CD4 (p = 0,014) e maior freqüência de doença neurológica clinicamente estável, embora não tenha havido diferença no perfil etiológico das complicações neurológicas. As doenças neurológicas continuam sendo causas freqüentes de complicações da infecção pelo HIV/AIDS no Brasil, e a despeito da terapia anti-retroviral altamente ativa, as infecções são ainda a principal etiologia das doenças do sistema nervoso.
Abstract
To study characteristics of neurological disorders in HIV/AIDS patients and their relationship to highly active antiretroviral treatment, a cross-sectional study was conducted in an infectious disease public hospital in Belo Horizonte, Brazil, between February 1999 and March 2000. Of the 417 patients enrolled, neurological disease was observed in 194 (46.5%) and a new AIDS-defining neurological event developed in 23.7% of individuals. Toxoplasmosis (42.3%), cryptococcosis meningitis (12.9%) and tuberculosis (10.8%) were the most common causes of neurological complications. The majority (79.3%) of patients were on highly active antiretroviral treatment and these individuals using HAART showed higher CD4 cell counts (p = 0.014) and presented stable neurological disease (p= 0.0001), although no difference was found with respect to the profile of neurological complications. The neurological diseases continue to be a frequent complication of HIV/AIDS and infections are still its main causes in Brazil, even in the highly active antiretroviral treatment era
Keywords in Portuguese
Infecção pelo HIVSIDA
Doença neurológica
Terapia anti-retroviral altamente ativa
Brasil
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