Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6583
Title: High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection
Authors: Lemos, Denise da Silveira
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Oliveira, Lúcia Fraga Alves
Oliveira, Rodrigo Corrêa de
Affilliation: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/ Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Doença de Chagas. Belo Horizonte, MG, Brasil
Universidade Vale do Rio Doce. Faculdade de Ciências da Saúde. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil
Abstract: Here in we have focused attention on major phenotypic features of peripheral blood eosinophils from chronic Schistosoma mansoni-infected patients. For this purpose, detailed immunophenotypic profiles of a range of cell surface markers were performed, including activation markers (CD23/CD69/CD25/HLA-DR), co-stimulatory mol-ecules (CD28/CD80/CD86), chemokine receptors (CXCR1/CXCR2/CCR3/CCR5) besides L-selectin-CD62L and adhesion molecules (CD18/CD54). Our major findings pointed out increased frequency of CD23 + -cells, besides decreased percentages of CD69 + -eosinophils, suggesting a chronic activation status with low frequency of early activated eosinophils in chronic S. mansoni-infected patients (INT) in comparison to non-infected individuals (NI). Moreover, a dichotomic expression of beta-chemokine receptors was observed during human schistosomiasis mansoni with higher CCR5 and lower levels of CCR3 observed between groups. Enhanced expression of co-stimulatory receptors (CD28/CD86) and adhesion molecules (CD54/CD18), besides striking lower frequency of L-selectin + were reported for eosinophils from INT group as compared to NI. Interestingly, the frequency of CD62L+ -eosinophils and a range of cell activation related molecules pointed out an opposite pattern of association in NI and INT, where only INT patients that display lower frequency of CD62L + -eosinophils (first CD62L tertile) kept the unusual rela-tionship between the expression of L-selectin and the CD23 activation marker. These findings suggest that distinct dynamic of activation markers expressed by eosinophils may occur during chronic S. mansoni infection.
Keywords: Schistosomiasis
Eosinophils
Activation markers
L-selectin
Issue Date: 2006
Citation: SILVEIRA-LEMOS, Denise et al. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz . 2006, vol.101, suppl.1, pp. 345-351
DOI: org/10.1590/S0074-02762006000900056
ISSN: 0074-0276
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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