| Author | Lemos, Denise da Silveira | |
| Author | Carvalho, Andréa Teixeira | |
| Author | Martins Filho, Olindo Assis | |
| Author | Oliveira, Lúcia Fraga Alves | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Access date | 2013-06-12T18:33:20Z | |
| Available date | 2013-06-12T18:33:20Z | |
| Document date | 2006 | |
| Citation | SILVEIRA-LEMOS, Denise et al. High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection. Mem. Inst. Oswaldo Cruz . 2006, vol.101, suppl.1, pp. 345-351 | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/6583 | |
| Sponsorship | CPqRR/Fiocruz, CNPq, National Institutes
of Health (PA- 98-078) | pt_BR |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | High expression of co-stimulatory and adhesion molecules are observed on eosinophils during human Schistosoma mansoni infection | pt_BR |
| Type | Article | pt_BR |
| DOI | org/10.1590/S0074-02762006000900056 | |
| Abstract | Here in we have focused attention on major phenotypic features of peripheral blood eosinophils from chronic Schistosoma mansoni-infected patients. For this purpose, detailed immunophenotypic profiles of a range of cell surface markers were performed, including activation markers (CD23/CD69/CD25/HLA-DR), co-stimulatory mol-ecules (CD28/CD80/CD86), chemokine receptors (CXCR1/CXCR2/CCR3/CCR5) besides L-selectin-CD62L and adhesion molecules (CD18/CD54). Our major findings pointed out increased frequency of CD23 + -cells, besides decreased percentages of CD69 + -eosinophils, suggesting a chronic activation status with low frequency of early activated eosinophils in chronic S. mansoni-infected patients (INT) in comparison to non-infected individuals (NI).
Moreover, a dichotomic expression of beta-chemokine receptors was observed during human schistosomiasis mansoni with higher CCR5 and lower levels of CCR3 observed between groups. Enhanced expression of co-stimulatory receptors (CD28/CD86) and adhesion molecules (CD54/CD18), besides striking lower frequency of L-selectin + were reported for eosinophils from INT group as compared to NI. Interestingly, the frequency of CD62L+ -eosinophils and a range of cell activation related molecules pointed out an opposite pattern of association in NI and INT, where only INT patients that display lower frequency of CD62L + -eosinophils (first CD62L tertile) kept the unusual rela-tionship between the expression of L-selectin and the CD23 activation marker. These findings suggest that distinct dynamic of activation markers expressed by eosinophils may occur during chronic S. mansoni infection. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/ Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Doença de Chagas. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Vale do Rio Doce. Faculdade de Ciências da Saúde. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | Eosinophils | pt_BR |
| Subject | Activation markers | pt_BR |
| Subject | L-selectin | pt_BR |
