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A COMPARATIVE ANALYSIS OF INNATE IMMUNE RESPONSES AND THE STRUCTURAL CHARACTERIZATION OF SPIKE FROM SARS-COV-2 GAMMA VARIANTS AND SUBVARIANTS
Produção científica do Laboratório de Vírus Respiratório e do Sarampo (vigente até jan/2023).
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Affilliation
Abstract
The SARS-CoV-2 P.1 variant, responsible for an outbreak in Manaus, Brazil, is distinguished by 12 amino acid differences in the S protein, potentially increasing its ACE-2 affinity and immune evasion capability. We investigated the innate immune response of this variant compared to the original B.1 strain, particularly concerning cytokine production. Blood samples from three severe COVID-19 patients were analyzed post-infection with both strains. Results showed no significant difference in cytokine production of mononuclear cells and neutrophils for either variant. While B.1 had higher cytopathogenicity, neither showed viral replication in mononuclear cells. Structural analyses of the S protein highlighted physicochemical variations, which might be linked to the differences in infectivity between the strains. Our studies point out to the increased infectivity of P.1 could stem from altered immunogenicity and receptor-binding affinity.
Publisher
MDPI
Citation
SCOVINO, Aline Miranda et al. A comparative analysis of innate immune responses and the structural characterization of spike from SARS-CoV-2 gamma variants and subvariants. Microorganisms, v. 12, n. 4, p. 1-19, 2 Apr. 2024.DOI
10.3390/microorganisms12040720ISSN
2076-2607Notes
Produção científica do Laboratório de Imunoparasitologia.Produção científica do Laboratório de Vírus Respiratório e do Sarampo (vigente até jan/2023).
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