| Author | Sant'Anna, Thaís Barbosa Ferreira | |
| Author | Martins, Thaynara Lorrane Silva | |
| Author | Carneiro, Megmar Aparecida dos Santos | |
| Author | Teles, Sheila Araujo | |
| Author | Caetano, Karlla Antonieta Amorim | |
| Author | Araujo, Natalia Motta de | |
| Access date | 2024-10-04T16:28:38Z | |
| Available date | 2024-10-04T16:28:38Z | |
| Document date | 2024 | |
| Citation | SANT'ANNA, Thaís Barbosa Ferreira et al. First detection of hepatitis B virus subgenotype A5, and characterization of occult infection and hepatocellular carcinoma-related mutations in latin american and african immigrants in Brazil. International Journal of Molecular Sciences, v. 25, n. 16, p. 1-16, 7 Aug. 2024. | |
| ISSN | 1661-6596 | |
| URI | https://www.arca.fiocruz.br/handle/icict/66309 | |
| Description | Produção científica do Laboratório de Virologia e Parasitologia Molecular. | pt_BR |
| Sponsorship | This research was funded by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), grant number E-26/210.450/2019, and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), grant number 309649/2022-6. | |
| Language | eng | en_US |
| Publisher | MDPI | |
| Rights | open access | |
| Title | First detection of hepatitis B virus subgenotype A5, and characterization of occult infection and hepatocellular carcinoma-related mutations in latin american and african immigrants in Brazil | en_US |
| Type | Article | |
| DOI | 10.3390/ijms25168602 | |
| Abstract | This study aims to characterize the molecular profile of the hepatitis B virus (HBV) among socially vulnerable immigrants residing in Brazil to investigate the introduction of uncommon HBV strains into the country. Serum samples from 102 immigrants with positive serology for the HBV core antibody (anti-HBc) were tested for the presence of HBV DNA by PCR assays. Among these, 24 were also positive for the HBV surface antigen (HBsAg). The full or partial genome was sequenced to determine genotype by phylogenetic analysis. Participants were from Haiti (79.4%), Guinea-Bissau (11.8%), Venezuela (7.8%), and Colombia (1%). Of the 21 HBV DNA-positive samples, subgenotypes A1 (52.4%), A5 (28.6%), E (9.5%), F2 (4.8%), and F3 (4.8%) were identified. Among the 78 HBsAg-negative participants, four were positive for HBV DNA, resulting in an occult HBV infection rate of 5.1%. Phylogenetic analysis suggested that most strains were likely introduced to Brazil by migration. Importantly, 80% of A5 sequences had the A1762T/G1764A double mutation, linked to an increased risk of hepatocellular carcinoma development. In conclusion, this study is the first report of HBV subgenotype A5 in Brazil, shedding new light on the diversity of HBV strains circulating in the country. Understanding the genetic diversity of HBV in immigrant communities can lead to better prevention and control strategies, benefiting both immigrants and wider society. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia e Parasitologia Molecular. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Federal University of Goiás. Faculty of Nursing. Goiânia, GO, Brasil. | |
| Affilliation | Federal University of Goiás. Institute of Tropical Medicine and Public Health. Goiânia, GO, Brasil. | |
| Affilliation | Federal University of Goiás. Faculty of Nursing. Goiânia, GO, Brasil. | |
| Affilliation | Federal University of Goiás. Faculty of Nursing. Goiânia, GO, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia e Parasitologia Molecular. Rio de Janeiro, RJ, Brasil. | |
| Subject | HBV | en_US |
| Subject | Molecular epidemiology | en_US |
| Subject | Genotypes | en_US |
| Subject | Phylogenetic analysis | en_US |
| Subject | Immigration | en_US |
| e-ISSN | 1422-0067 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
| xmlui.metadata.dc.subject.ods | 17 Parcerias e meios de implementação | |
