| Author | Fuzikawa, Alberto Kazuo | |
| Author | Peixoto, Sérgio William Viana | |
| Author | Taufer, Maristela | |
| Author | Moriguchi, Emílio Hideyuki | |
| Author | Costa, Maria Fernanda Lima | |
| Access date | 2013-07-04T17:24:49Z | |
| Available date | 2013-07-04T17:24:49Z | |
| Document date | 2008 | |
| Citation | FUZIKAWA, Alberto Kazuo et al. Association of ApoEpolymorphisms withprevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS). ApoEpolymorphism and hypertension in the elderly. Brazilian Journal of Medical and Biological Research, n. 41, p. 89-94, 2008. | pt_BR |
| ISSN | 0100-879X | |
| URI | https://www.arca.fiocruz.br/handle/icict/6648 | |
| Sponsorship | CNPq | pt_BR |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS) | pt_BR |
| Type | Article | pt_BR |
| Abstract | Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controver-sial. The objective of this study was to examine the association between ApoEpolymorphism and prevalent hypertension in a large unselected population of older adults. Participants from the baseline of the Bambuí Health Aging Study whose ApoE genes had been genotyped were selected for this study (N = 1406, aged 60-95 years). These subjects represented 80.7% of the total elderly residents in Bambuí city, MG, Brazil. Hypertension was defined as a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg, or the use of anti-hypertensive medication. The exposure variable was the ApoEgenotype as follows: ε3 carriers, ε3ε3; ε2 carriers, ε2ε2 or ε2ε3, and ε4 carriers, ε3ε4 or ε4ε4. Potential confounding variables were age, gender, traditional cardiovascular risk factors, uric acid, and creatinine levels. The prevalence of hypertension was 61.3%.
Compared with the ε3 homozygotes, neither the ε2 nor the ε4 carrier status was associated with hypertension (adjusted prevalence ratios = 0.94, 95%CI = 0.83-1.07 and 0.98, 0.89-1.07, respectively). On the other hand, the ε2 allele carriers had lower LDL cholesterol levels (P < 0.001) and the ε4 carriers had higher LDL cholesterol levels (P = 0.036). This study provides epidemiologic evidence that the ApoEgenotype is not associated with prevalent hypertension in old age. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil
/ Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | CMIC Brasil Pesquisas Clínicas. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brasil / Universidade do Vale dos Sinos. Porto Alegre, RS, Brasil / Hospital Moinhos de Vento de Porto Alegre. Porto Alegre, RS, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Apolipoprotein E | pt_BR |
| Subject | Hypertension | pt_BR |
| Subject | Low-density lipoprotein cholesterol | pt_BR |
| Subject | Triglycerides | pt_BR |
| Subject | Lipid metabolism | pt_BR |
