Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6666
Title: Urban transmission of Chagas disease in Cochabamba, Bolivia
Authors: Mercado, Nora Medrano
Fernandez, R. Ugarte
Butrón, V.
Uber-Busek, Solange Cristina
Guerra, H. L.
Araujo-Jorge, Tania C.
Oliveira, Rodrigo Corrêa de
Affilliation: Universidad Mayor de San Simón. Faculdade de Ciencias y Tecnología. Departamento de Biología. Laboratorio de Chagas e Inmunoparasitologia. Cochabamba, Bolivia.
Universidad Mayor de San Simón. Faculdade de Ciencias y Tecnología. Departamento de Biología. Laboratorio de Chagas e Inmunoparasitologia. Cochabamba, Bolivia.
Universidad Mayor de San Simón. Faculdade de Ciencias y Tecnología. Departamento de Biología. Laboratorio de Chagas e Inmunoparasitologia. Cochabamba, Bolivia.
Universidad Mayor de San Simón. Faculdade de Ciencias y Tecnología. Departamento de Biología. Laboratorio de Chagas e Inmunoparasitologia. Cochabamba, Bolivia.
Universidad Mayor de San Simón. Faculdade de Ciencias y Tecnología. Departamento de Biología. Laboratorio de Chagas e Inmunoparasitologia. Cochabamba, Bolivia.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Laboratório Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
Abstract: Chagas disease is a major public health problem in Bolivia. In the city of Cochabamba, 58% of the population lives in peripheral urban districts ("popular zones") where the infection prevalence is extremely high. From 1995 to 1999, we studied the demographics of Chagas infections in children from five to 13 years old (n = 2218) from the South zone (SZ) and North zone (NZ) districts, which differ in social, environmental, and agricultural conditions. Information gathered from these districts demonstrates qualitative and quantitative evidence for the active transmission of Trypanosoma cruzi in urban Cochabamba. Seropositivity was high in both zones (25% in SZ and 19% in NZ). We observed a high risk of infection in children from five to nine years old in SZ, but in NZ, a higher risk occurred in children aged 10-13, with odds ratio for infection three times higher in NZ than in SZ. This difference was not due to triatomine density, since more than 1,000 Triatoma infestans were captured in both zones, but was possibly secondary to the vector infection rate (79% in SZ and 37% in NZ). Electrocardiogram abnormalities were found to be prevalent in children and pre-adolescents (SZ = 40%, NZ = 17%), indicating that under continuous exposure to infection and re-infection, a severe form of the disease may develop early in life. This work demonstrates that T. cruzi infection should also be considered an urban health problem and is not restricted to the rural areas and small villages of Bolivia.
Keywords: Chagas Disease
Acute phase
Risk factors
Children
Bolivia
EKG abnormalities
Issue Date: 2008
Citation: MERCADO, Nora Medrano et al. Urban transmission of Chagas disease in Cochabamba, Bolivia. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 5, p. 423-430, Aug. 2008.
DOI: 10.1590/S0074-02762008000500003.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
MG - IRR - Artigos de Periódicos

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