| Author | Silva, Patrício Braz da | |
| Author | Diniz, Clara Pinto | |
| Author | Mediano, Mauro Felippe Felix | |
| Author | Mendes, Fernanda de Souza Nogueira Sardinha | |
| Author | Hasslocher-Moreno, Alejandro Marcel | |
| Author | Reis, Luis Felipe da Fonseca | |
| Author | Reis, Michel Silva | |
| Author | Saraiva, Roberto Magalhães | |
| Author | Holanda, Marcelo Teixeira de | |
| Author | Rocha, Flavia Mazzoli da | |
| Author | Sousa, Andréa Silvestre de | |
| Access date | 2024-11-06T13:10:20Z | |
| Available date | 2024-11-06T13:10:20Z | |
| Document date | 2025 | |
| Citation | SILVA, Patrício Braz da et al. Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity. Heart & Lung: The Journal of Cardiopulmonary and Acute Care, v. 69, p. 222-228, Jan./Feb. 2025. | |
| ISSN | 0147-9563 | |
| URI | https://www.arca.fiocruz.br/handle/icict/66997 | |
| Sponsorship | The authors thank the Evandro Chagas National Institute of Infectious Disease for the clinical and logistical support. This study was supported by The Carlos Chagas Filho Rio de Janeiro State Research Supporting Foundation [FAPERJ ARC/2019 – PROC SEI E-26/211.324/2019]. The founders played no role in this study's design, conduct, or reporting. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Title | Heart failure associated with chronic Chagas cardiomyopathy increases the risk of impaired lung function and reduced submaximal functional capacity | en_US |
| Type | Article | |
| DOI | 10.1016/j.hrtlng.2024.10.009 | |
| Abstract | Background: With the evolution of chronic Chagas cardiomyopathy (CC) and the progression towards heart failure (HF), patients may show a decline in inspiratory muscle strength, lung function, and functional capacity. Objective: We compared respiratory function and submaximal functional capacity in patients with CC with versus without HF. Methods: This observational, cross-sectional study was carried out with CC patients divided into CCG, a group without HF (n = 28), and HFG, a group with HF (n = 27). Spirometry (percent predicted forced vital capacity (ppFVC), forced expiratory volume in one second of FVC (ppFEV₁), forced expiratory flow between 25 % and 75 % of FVC (ppFEF₂₅-₇₅ ﹪), and maximum voluntary ventilation (ppMVV)) and submaximal functional capacity (six-minute step test: 6MST) were evaluated. Mann-Whitney (comparison of pulmonary function and functional capacity between groups) and linear regression (association between the presence of HF and other variables) were performed. Results: We included 55 participants, with median age of 67 years (56.25–71.75) and 54.55 % males. Dyslipidemia was the most recurrent comorbidity (49.09 %). HFG presented lower ppFVC (P = 0.000), ppFEV₁ (P = 0.011), ppFEF₂₅-₇₅ ﹪ (P = 0.017), and ppMVV (P = 0.003) than the CCG. The ppFVC (B = -18.95; P = 0.000), ppFEV₁ (B = -16.29; P = 0.021), ppFEF₂₅-₇₅ ﹪ (B = -19.57; P = 0.014), ppMVV (B = -16.59; P = 0.003), and 6MST (B = -17.13; P = 0.034) were negatively associated with the presence of HF. Conclusion: Our data suggest that impaired lung function, compatible with a restrictive pulmonary pattern, is present among adults with CC and HF. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cardiologia. Coordenação de Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Centro Universitário Augusto Motta. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | |
| Subject | Chagas cardiomyopathy | en_US |
| Subject | Spirometry | en_US |
| Subject | Submaximal functional capacity | en_US |
| Subject | Six-minute step test | en_US |
| Subject | Lung function | en_US |
| e-ISSN | 1527-3288 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
