| Author | Duarte, Rener Mateus Francisco | |
| Author | Barbosa, Erika Renata Ribeiro | |
| Author | Ferreira, Frederico Rogério | |
| Author | Espindola, Foued Salmen | |
| Author | Spini, Vanessa Beatriz Monteiro Galassi | |
| Access date | 2024-11-26T18:45:59Z | |
| Available date | 2024-11-26T18:45:59Z | |
| Document date | 2025 | |
| Citation | DUARTE, Rener Mateus Francisco et al. Resveratrol prevents offspring's behavioral impairment associated with immunogenic stress during pregnancy. Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 136, n. 111188, p. 1-12, 10 Jan. 2025. | |
| ISSN | 0278-5846 | |
| URI | https://www.arca.fiocruz.br/handle/icict/67298 | |
| Description | Produção científica do Laboratório de Fisiopatologia Clínica e Experimental. | pt_BR |
| Sponsorship | The authors gratefully acknowledge the Biomedical Science Institute of the Federal University of Uberlândia (UFU). The authors would also like to express their appreciation to the Dean of Research and Graduate Studies (Pró-Reitoria de Pesquisa e Pós-graduação - PROPP/ UFU), the Biotechnology Institute (UFU), and the Rodent Biotery Network (REBIR) at UFU.Foued Salmen Espindola is supported by a grant from Fundação de Amparo à Pesquisa do Estado de Minas Gerais–FAPEMIG [Rede Mineira de Pesquisa Translacional em Imunobiológicos e Biofármacos no Câncer (REMITRIBIC, RED-00031-21) and the National Institute of Science and Technology in Theranostics and Nanobiotechnology—INCT—TeraNano (CNPq grant # 465669/2014-0,que http://www.teranano.ufu.br/) and Frederico Rogério Ferreira is support from PON-IOC. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Title | Resveratrol prevents offspring's behavioral impairment associated with immunogenic stress during pregnancy | en_US |
| Type | Article | |
| DOI | 10.1016/j.pnpbp.2024.111188 | |
| Abstract | Evidence suggests that prenatal maternal immunological stress is associated with an increased risk of neurological and psychiatric disorders in the developing offspring. Protecting the embryo during this critical period of neurodevelopment, when the brain is especially vulnerable, is therefore crucial. Polyphenols, with their antioxidant and anti-inflammatory properties, offer promising therapeutic approaches. This study demonstrated a series of behavioral changes induced by maternal immune activation (MIA) triggered by an antigenic solution derived from the H1N1 virus. These changes include significant differences in anxiety and risk assessment behaviors, increased immobility in the forced swim test, impairments in memory and object recognition, and social deficits resembling autism. The phenolic compound resveratrol (RSV) was evaluated for its in vitro antioxidant capacity and characterized using infrared spectroscopy. Administering RSV from embryonic day 14 (E14) to embrionyc day 19 (E19) during MIA effectively reduced its harmful effects on the offspring. This was evidenced by a significant restoration of social behaviors, memory, and recognition, as well as anxiolytic and antidepressant effects in the adult offspring. These findings contribute to new therapeutic strategies for preventing psychiatric disorders associated with neurodevelopmental stressors. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Biotecnologia. Departamento de Bioquímica e Biologia Molecular. Uberlândia, MG, Brasil. | |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Departamento de Fisiologia. Uberlândia, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Biotecnologia. Departamento de Bioquímica e Biologia Molecular. Uberlândia, MG, Brasil. | |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Departamento de Fisiologia. Uberlândia, MG, Brasil. | |
| Subject | Psychiatric disorders | en_US |
| Subject | Maternal immune activation | en_US |
| Subject | Influenza antigens | en_US |
| Subject | Resveratrol | en_US |
| Subject | Neurodevelopment | en_US |
| e-ISSN | 1878-4216 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
| xmlui.metadata.dc.subject.ods | 17 Parcerias e meios de implementação | |
