Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6772
Title: Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes.
Authors: Rebolledo, Anayive Pérez
Ayala, José Danilo
Lima, Geraldo Magela de
Beraldo, Heloisa
Marchini, Nicoletta
Bombieri, Gabriella
Zani, Carlos Leomar
Fagundes, Elaine Maria de Souza
Affilliation: Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil.
Università di Milano. Istituto di Chimica Farmaceutica e Tossicologica. Milano, Italy.
Università di Milano. Istituto di Chimica Farmaceutica e Tossicologica. Milano, Italy.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.
Abstract: Structural studies and an investigation of the cytotoxic activity of Sn(IV) complexes with N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) were carried out. The crystal and molecular structures of [Sn(2Bz4Ph)Cl3].CH3CH2OH (1) and [Sn(2Bz4Ph)BuCl2].H2O (Bu = butyl group) (2) were determined. Both compounds present octahedral coordination geometry with the 2Bz4Ph anionic ligand behaving as tridentate on the metal ion. A comparative study of the structures of these compounds along with that of [Sn(2Bz4Ph)Bu2Cl] (3) determined before is presented. The cytotoxicity of H2Bz4Ph and its Sn(IV) complexes was investigated against the MCF-7, TK-10 and UACC-62 human tumor cell lines. Among the three complexes, 3 proved to be better as cytotoxic agent than the clinically used drug etoposide. H2Bz4Ph and all complexes were able to induce apoptosis in UACC-62 cells.
DeCS: Thiosemicarbazones
Tin(IV) complexes
Crystal structures
Cytotoxic activity
Issue Date: 2005
Publisher: Elsevier
Citation: PEREZ-REBOLLEDO, Anayive et al. Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes. Eur J Med Chem., v. 40, n. 5, p. 467-472, May 2005.
ISSN: 0223-5234
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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