Ozone therapy in the integrated treatment of female dogs with mammary cancer: oxidative profile and quality of life

Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunologia e Biologia Molecular. Salvador, BA, Brasil.
Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária. Salvador, BA, Brasil / Universidade Federal do Recôncavo da Bahia. Ciências Ambientais e Biológicas. Centro de Agricultura. Cruz das Almas, BA, Brasil.
Universidade Federal da Bahia. Instituto de Química. Departamento de Química Analítica. Salvador, BA, Brasil.
Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Clínica Veterinária. Salvador, BA, Brasil.
Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Química. Departamento de Química Analítica. Salvador, BA, Brasil.
Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.
Faculty of Veterinary Medicine. Lusofona University. Lisbon, Portugal.
Faculty of Veterinary Medicine. Lusofona University. Lisbon, Portugal / Veterinary and Animal Research Centre (CECAV). Faculty of Veterinary Medicine, Lusofona University. Lisbon, Portugal / Mediterranean Institute for Agriculture. Environment and Development. Universidade de Évora. Évora, Portugal.
Universidade Federal da Bahia. Centro de Pesquisa em Oncologia Mamária. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Clínica Veterinária. Salvador, BA, Brasil.

Abstract

Considering the high frequency of malignant breast tumors, there is a growing search for new therapeutic strategies that control neoplastic growth and dissemination, combined with fewer adverse reactions. Therefore, this study evaluated the effects of ozone therapy in female dogs with mammary cancer undergoing chemotherapy treatment. Twenty-five canines diagnosed with malignant mammary neoplasia were divided into two groups: one treated with carboplatin alone (n = 11) and the other with carboplatin associated with ozone therapy (n = 14). Clinical and laboratory evaluations, mastectomy, analysis of the oxidative profile based on total antioxidant capacity (TAC) and serum concentrations of malondialdehyde (MDA), survival rate, and quality of life were performed. Animals in the ozone therapy group had higher concentrations of red blood cells and platelets, significantly improving the survival rate and quality of life. Furthermore, adverse reactions were less intense and frequent in this group, which was associated with an increase in TAC and a reduction in MDA. These results indicate that the combination of carboplatin and ozone therapy represents a promising complementary treatment for female dogs with mammary cancer, as it was associated with fewer adverse reactions and a better oxidative profile

Keywords

Breast cancer
Chemotherapy-induced side effects
Integrative medicine
Ozone
Reactive oxygen species

DeCS

Neoplasias da mama
Tratamento farmacológico
Medicina integrativa
Ozônio
Espécies reativas de oxigênio

Publisher

MDPI

Citation

SILVA, Laís Pereira et al. Ozone therapy in the integrated treatment of female dogs with mammary cancer: oxidative profile and quality of life. Antioxidants, v. 13, n. 673, p. 1-21, 2024.

DOI

10.3390/ antiox13060673

ISSN

2076-3921

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/67930

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Open access

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