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PreprintCopyright
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Embargo date
3100-12-31
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- MG - IRR - Preprint [62]
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HUMAN PEGIVIRUS -1 (HPGV-1) RNA FREQUENCY AND GENOTYPE DISTRIBUTION IN PEDIATRIC ONCOLOGY PATIENTS WITH FEBRILE NEUTROPENIA
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Abstract
Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its Frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0 % among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations.
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