| Author | Oliveira, Adrhyan Araújo da Silva | |
| Author | Silva, Ana Maisa Passos da | |
| Author | Queiroz, Jackson Alves da Silva | |
| Author | Souza, Paulo Ricardo Freitas de | |
| Author | Salcedo, Juan Miguel Villalobos | |
| Author | Vieira, Deusilene Souza | |
| Access date | 2025-01-16T15:51:13Z | |
| Available date | 2025-01-16T15:51:13Z | |
| Document date | 2022 | |
| Citation | OLIVEIRA, Adrhyan Araújo da Silva et al. ACE2 and TMPRSS2 polymorphisms and the development of COVID-19: a review of the literature. International Journal of Clinical Virology, v. 6, p. 17-23, 28 Apr. 2022. | en_US |
| ISSN | 2692-4994 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68102 | |
| Language | eng | en_US |
| Publisher | Heighten Science Publications Inc | en_US |
| Rights | open access | en_US |
| Title | ACE2 and TMPRSS2 polymorphisms and the development of COVID-19: a review of the literature | en_US |
| Type | Article | en_US |
| DOI | 10.29328/journal.ijcv.1001044 | |
| Abstract | SARS-CoV-2 is a virus that has a positive-sense, single-stranded RNA genome that encodes 4 structural proteins, the main one being the S protein (Spike) responsible for mediating with ACE2 and TMPRSS2 for entry into the host cell. The study of single nucleotide polymorphisms (SNPs) of ACE2 and TMPRSS2 can elucidate their possible intervention in the action of the protein, its activity, and the gene expression of encoding these enzymes, which may increase susceptibility to viral infection. From this, literature searches were carried out until December 2021, listing 11,820 publications for literary analysis on the described genetic variations of these protein structures, as well as their relation and infl uence on the pathology. It was possible to conclude that there is a great infl uence exerted by genetic variability in ACE2 and TMPRSS2 increasing the ability of the virus to bind to the host cell and the development of COVID-19 with complications. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil / Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil / Fundação Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil / Fundação Universidade Federal de Rondônia. Programa de Pós-Graduação em Biologia Experimental. Porto Velho, RO, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil / Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. | en_US |
| Affilliation | Fundação Universidade Federal de Rondônia. Porto Velho, RO, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Rondônia. Laboratório de Virologia Molecular. Porto Velho, RO, Brasil / Centro de Pesquisa em Medicina Tropical. Porto Velho, RO, Brasil. | en_US |
| Subject | Polymorphisms | en_US |
| Subject | ACE2 | en_US |
| Subject | TMPRSS2 | en_US |
| Subject | COVID-19 | en_US |
| Subject | Susceptibility | en_US |
| DeCS | Polymorphism, Genetic | en_US |
| DeCS | Angiotensin-Converting Enzyme 2 | en_US |
| DeCS | COVID-19 | en_US |
