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TRACING THE DISPERSAL PATHWAY OF HIV-1 SUBTYPE C TO BAHIA: PHYLOGENETIC CONNECTIONS TO SOUTHERN BRAZIL.
Polita, Daniel et al. | Date Issued: 2024
Author
Polita, Daniel
Moraes, Laise de
Giovanetti, Marta
Rego, Filipe Ferreira de Almeida
Santos, Luciane Amorim
Junqueira, Dennis Maletich
Khouri, Ricardo
Affilliation
Universidade Federal de Santa Maria. Programa de Pós-Graduação em Ciências Biológicas: Bioquímica. Laboratório de Bioinformática e Evolução Viral. Santa Maria, RS, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. / Universidade Federal da Bahia. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil.
Sciences and Technologies for Sustainable Development and One Health. University of Campus Bio-Medico. Rome, Italy. / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. / Universidade Federal da Bahia. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil. / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Universidade Federal de Santa Maria. Programa de Pós-Graduação em Ciências Biológicas: Bioquímica. Laboratório de Bioinformática e Evolução Viral. Santa Maria, RS, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. / Universidade Federal da Bahia. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Salvador, BA, Brasil. / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. / Rega Institute for Medical Research. Department of Immunology, Microbiology and Transplantation. KU Leuven. Leuven, Belgium.
Abstract
The HIV-1 epidemic in Brazil is predominantly characterized by subtype B, except in the southern states, where subtype C (HIV-1C) is more prevalent. Continuous monitoring of this profile is essential to maintain an accurate understanding of the molecular landscape of the HIV epidemic in Brazil. In this study, we isolated and sequenced seven new HIV-1C strains from the state of Bahia, located in the Northeast region of Brazil. To reconstruct the phylogenetic history of HIV-1C in the Northeast and investigate its connections with other regions of the country and globally, we first compiled a dataset of 3631 HIV-1C sequences from Brazil, Africa, and Europe. As expected, most of the new HIV-1C sequences from Bahia (n = 6) clustered within the well-known Brazilian clade. However, one sequence from Bahia clustered within the African clade, suggesting a possible new introduction of HIV-1C into Brazil. Furthermore, our findings indicate that the HIV-1C cases in Bahia likely originated from southern states, particularly Santa Catarina. This study provides valuable insights into the molecular profile of the HIV epidemic in Brazil, expanding our understanding of HIV-1C beyond the Southern region.
Keywords
Bahia
Brazil
HIV-1
Subtype C
Epidemics
Molecular phylogenetics
Transmission of infectious disease
 
Publisher
MDPI
Citation
POLITA, Daniel et al. Tracing the Dispersal Pathway of HIV-1 Subtype C to Bahia: Phylogenetic Connections to Southern Brazil. Viruses, v. 16, n. 12, 1941, 2024.
DOI
10.3390/v16121941
ISSN
1999-4915