Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/68457

Type
Article
Copyright
Open access
Collections
Share

Statistics
Metadata
Show full item record

DENGUE VIRUS–SPECIFIC ANTIBODIES ENHANCE BRAZILIAN ZIKA VIRUS INFECTION
Castanha, Priscila M. S. et al. | Date Issued: 2017
Author
Castanha, Priscila M. S.
Nascimento, Eduardo J. M.
Braga, Cynthia
Cordeiro, Marli T.
Carvalho, Otávio V. de
Mendonça, Leila R. de
Azevedo, Elisa A. N.
França, Rafael F. O.
Dhalia, Rafael
Marques, Ernesto T. A.
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil / Universidade de Pernambuco. Instituto de ciência biológica. Faculdade de Ciência Medica. Recife. PE, Brasil.
Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. Department of Infectious Disease and Microbiology. Pennsylvania, USA.
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil / Universidade Federal de Viçosa. Viçosa, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Recife, PE, Brasil / Center for Vaccine Research. Pittsburgh, USA / University of Pittsburgh. Department of Infectious Disease and Microbiology. Pennsylvania, USA.
Abstract
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infec tion of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum sam ples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complica tions associated with ZIKV infections.
Keywords
Zika virus
Antibody dependent enhancement
Dengue antibodies
 
Publisher
Oxford University Press
Citation
CASTANHA, Priscila MS et al. Dengue virus–specific antibodies enhance Brazilian Zika virus infection. The Journal of infectious diseases, v. 215, n. 5, p. 781-785, 2017.
DOI
10.1093/infdis/jiw638
ISSN
1537-6613