Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis

Fundação Oswaldo Cruz. Fiocruz Rondônia. Laboratório de Biotecnologia de Proteínas e Compostos Bioativos. Porto Velho, RO, Brasil / Sao Lucas University Center. Porto Velho, RO, Brasil / Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental. Porto Velho, RO, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Federal University of Pará. Postgraduate Program in Neuroscience and Cell Biology. Belém, PA, Brasil.
Universidad del Valle de Guatemala. Department of Biochemistry and Microbiology. Guatemala, GT, Guatemala.
State University of Amazonas. Postgraduate Program in Tropical Medicine. Manaus, AM, Brasil / Universidad de San Carlos de Guatemala. Faculty of Medical Sciences. Guatemala City, Guatemala.
Federal University of Pará. Faculty of Pharmacy. Postgraduate Program in Pharmaceutical Sciences. Belém, PA, Brasil.
Federal University of Pará. Institute of Biological Science. Laboratory of Pharmacology and Toxicology of Cardiovascular System. Belém, PA, Brasil.
Fundação Oswaldo Cruz. Fiocruz Rondônia. Instituto Nacional de Ciência e Tecnologia de Epidemiologia da Amazônia Ocidental. Porto Velho, RO, Brasil / Universidade Estadual Paulista. Institute for Advanced Studies of the Sea. São Vicente, SP, Brasil / Universidade Estadual Paulista. Institute of Biosciences. Department of Biophysics and Pharmacology. Botucatu, SP, Brasil.
Federal University of Pará. Postgraduate Program in Neuroscience and Cell Biology. Belém, PA, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.

Abstract

Central America is home to one of themost abundant herpetofauna in the Americas, occupying only 7% of the continent’s total area. Vipers and lizards are among themost relevant venomous animals in medical practice due to the consequences of envenomation fromthe bite of these animals. A great diversity of biomoleculeswith immense therapeutic and biotechnological value is contained in their venom. This paper describes the prominent leading representatives of the familyViperidae, emphasizing theirmorphology, distribution, habitat, feeding, and venomcomposition, as well as the biotechnological application of some isolated components from the venom of the animals from these families, focusing on molecules with potential anti-thrombotic action. We present the leading protein families that interfere with blood clotting, platelet activity, or the endotheliumpro-thrombotic profile. In conclusion, Central America is an endemic region of venomous animals that can providemanymolecules for biotechnological applications.

Keywords

Viperidae
Venom
Envenomation
Biomolecules
Thrombosis

DeCS

Viperidae
Venoms
Venous Thrombosis

Publisher

MDPI

Citation

ESTRADA, Jorge Eduardo Chang et al. Potential Biotechnological Applications of Venoms from the Viperidae Family in Central America for Thrombosis. Toxins, v. 16, n. 142, p. 1-30, 8 Mar. 2024.

DOI

10.3390/toxins16030142

ISSN

2072-6651

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/68756

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Open access

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