| Author | Costa, Maria Fernanda Lima | |
| Author | Peixoto, Sérgio William Viana | |
| Author | Ribeiro, Antonio Luiz P. | |
| Author | Cesar, Cibele Comini | |
| Author | Ribeiro, Antonio Luiz P. | |
| Access date | 2013-09-17T14:38:35Z | |
| Available date | 2013-09-17T14:38:35Z | |
| Document date | 2010 | |
| Citation | COSTA, Maria Fernanda Lima et al. Plasma B-type natriuretic peptide as a predictor of mortality in community-dwelling older adults with Chagas disease: 10-year follow-up of the Bambui Cohort Study of Aging. American Journal of Epidemiology, v. 172, n. 2, p. 190-196, July 15, 2010. | pt_BR |
| ISSN | 0002-9262 | |
| URI | https://www.arca.fiocruz.br/handle/icict/6924 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Plasma B-type natriuretic peptide as a predictor of mortality in community-dwelling older adults with Chagas disease: 10-year follow-up of the Bambui Cohort Study of Aging | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/aje/kwq106 | |
| Abstract | In this study, the authors aimed to investigate the prognostic value of b-type natriuretic peptide (BNP) for all-cause mortality among persons with Chagas disease, a parasitic disease caused by the protozo na Trypanosoma cruzi. The authors used data on 1,398 participants (37.5% infected with T. cruzi) aged 60 years and over from the Bambuı´Cohort Study of Aging in Brazil. From 1997 to 2007, 512 participants died, leading to 12,406 person-years of observation. The hazard ratio for death was 1.27 for each unit of log-transformed BNP level (95% confidence interval (CI: 1.11, 1.45) among infected persons, independent of potentially confounding factors. Infected persons with baseline BNP levels in the top quartile had a risk of death twice that of persons in the bottom quartile (hazard ratio ¼ 2.07, 95% CI: 1.29, 3.32). The discriminatory ability of BNP in predicting mortality (C¼0.69, 95% CI: 0.66, 0.71) was similar to that of an electrocardiogram (C¼0.68, 95% CI: 0.65, 0.71), with reasonably stable risk discrimination over time. BNP is a strong predictor of mortality in older adults with Chagas disease. Although the usefulness of BNP for risk stratification in this parasitic disease remains a topic of debate, this study found that BNP-based risk discrimination is at least comparable to that of an electrocardiogram. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil / Universidade Federal de Ouro Preto. Escola de Nutrição, Ouro Preto, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Exatas. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clınicas. Belo Horizonte, MG, Brazil. | pt_BR |
| Subject | Aged | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | cohort studies | pt_BR |
| Subject | mortality | pt_BR |
| Subject | natriuretic peptides | pt_BR |
| Subject | prognosis | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
