| Author | Vilela, Márcia Carvalho | |
| Author | Lima, Graciela Kunrath | |
| Author | Rodrigues, David Henrique | |
| Author | Queiroz, Norinne Lacerda | |
| Author | Mansur, Daniel Santos | |
| Author | Miranda, Aline Silva de | |
| Author | Rachid, Milene Alvarenga | |
| Author | Kroon, Erna Geessien | |
| Author | Vieira, Leda Quércia | |
| Author | Campos, Marco Antônio da Silva | |
| Author | Teixeira, Mauro Martins | |
| Author | Teixeira, Antônio Lúcio | |
| Access date | 2013-10-03T19:27:17Z | |
| Available date | 2013-10-03T19:27:17Z | |
| Document date | 2010 | |
| Citation | VILELA, Márcia Carvalho et al. TNFR1 plays a critical role in the control of severe HSV-1 encephalitis. TNFR1 plays a critical role in the control of severe HSV-1 encephalitis. Neurosci Lett., v. 479, n. 1, p. 58-62, Jul. 2010. | pt_BR |
| ISSN | 0304-3940 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7085 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Ireland Ltd | pt_BR |
| Rights | restricted access | |
| Title | NFR1 plays a critical role in the control of severe HSV-1 encephalitis. TNFR1 plays a critical role in the control of severe HSV-1 encephalitis. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.neulet.2010.05.028 | |
| Abstract | Herpes simplex virus-1 (HSV-1) is a pathogen for humans that may cause severe encephalitis. Tumor necrosis factor (TNF- ) plays a role in several viral diseases of the central nervous system (CNS). The classic proinflammatory activities of TNF- are mediated mainly through activation of the receptor 1 for TNF- (TNFR1). However, when HSV-1 is inoculated in the periphery, TNF- seems to protect C57Bl/6 mice against encephalitis by a mechanism independent of TNFR1. This study aims to investigate the role of TNFR1 in HSV-1 encephalitis induced by the inoculation of the virus into the brain. Wild-type C57BL/6 (WT) and TNFR1 −/− were inoculated with 102 plaque-forming units of HSV-1 by the intracranial route. Infection with HSV-1 was lethal in TNFR1 −/− mice in early times after infection. TNFR1−/− mice had reduced expression of the chemokines CCL3 and CCL5, and decreased leukocyte adhesion in the brain vasculature compared to WT mice 4 days post-infection (dpi). At this time point TNFR1 −/− infected mice also had higher HSV-1 viral replication and more injuries in the brain, especially in the hippocampus. In conclusion, TNFR1 seems to play a relevant role in the control of viral replication in the CNS when HSV-1 is inoculated by intracranial route. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Insituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Insituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Insituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Insituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Insituto de Ciencias Biologicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Insituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Insituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Crz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Insituto de Ciencias Biologicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil. | pt_BR |
| Subject | Herpes simplex virus type 1 | pt_BR |
| Subject | TNFR1 | pt_BR |
| Subject | Neuroinflammation | pt_BR |
