Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7118
Title: Intrathecal cytokines in spinal cord schistosomiasis
Authors: Ferrari, Teresa Cristina de Abreu
Moreira, Paulo Roberto Rocha
Sampaio, Márcio José
Cunha, Aloísio Sales da
Oliveira, José Teotônio de
Gazzinelli, Giovanni
Oliveira, Rodrigo Correa de
Affilliation: Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Neurologia. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Serviço de Neurologia. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil
Abstract: We investigate the cytokine profile in the cerebrospinal fluid (CSF) and serum of patients with spinal cord schistosomiasis (SCS). Increased levels of IL-1β, IL-4, IL-6 and IL-10 and low concentrations of TNF-αand IFN-γwere observed in both CSF and serum. CSF showed higher levels of IL-4 and IL-6 when compared to the paired serum samples. A negative correlation between the concentrations of IL-10 and IFN-γwas observed in the CSF. These findings suggest an inflammatory as well as a skewed type-2 immune response that probably occur both locally and systemically and may be involved in the pathogenesis of SCS.
Keywords: Neuroschistosomiasis
Spinal cord disease
Cytokines
Cerebrospinal fluid
Schistosoma mansoni
Issue Date: 2006
Publisher: Elsevier/North-Holland
Citation: FERRARI, Teresa Cristina Abreu et al. Intrathecal cytokines in spinal cord schistosomiasis. J Neuroimmunol. 2006 Aug;177(1-2):136-41
ISSN: 0165-5728
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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