Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7259
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dc.contributor.authorMendonça, Vitor Rosa Ramos de
dc.contributor.authorQueiroz, Artur Trancoso Lopo de
dc.contributor.authorLopes, Fabrício M.
dc.contributor.authorAndrade, Bruno de Bezerril
dc.contributor.authorBarral Netto, Manoel
dc.date.accessioned2013-11-25T17:21:54Z
dc.date.available2013-11-25T17:21:54Z
dc.date.issued2013
dc.identifier.citationMENDONÇA, V. R. R. et al. Networking the host immune response in Plasmodium vivax malaria. Malaria Journal (Online), v.12, p. 69-78, 2013.
dc.identifier.issn1475-2875
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/7259
dc.language.isoeng
dc.publisherBioMed Central Ltd
dc.rightsopen access
dc.titleNetworking the host immune response in Plasmodium vivax malaria
dc.typeArticle
dc.identifier.doidoi:10.1186/1475-2875-12-69
dc.description.abstractenBackground: Plasmodium vivax malaria clinical outcomes are a consequence of the interaction of multiple parasite, environmental and host factors. The host molecular and genetic determinants driving susceptibility to disease severity in this infection are largely unknown. Here, a network analysis of large-scale data from a significant number of individuals with different clinical presentations of P. vivax malaria was performed in an attempt to identify patterns of association between various candidate biomarkers and the clinical outcomes. Methods: A retrospective analysis of 530 individuals from the Brazilian Amazon, including P. vivax-infected individuals who developed different clinical outcomes (148 asymptomatic malaria, 187 symptomatic malaria, 13 severe non-lethal malaria, and six severe lethal malaria) as well as 176 non-infected controls, was performed. Plasma levels of liver transaminases, bilirubins, creatinine, fibrinogen, C-reactive protein, superoxide dismutase (SOD)-1, haem oxygenase (HO)-1 and a panel composed by multiple cytokines and chemokines were measured and compared between the different clinical groups using network analysis. Results: Non-infected individuals displayed several statistically significant interactions in the networks, including associations between the levels of IL-10 and IL-4 with the chemokine CXCL9. Individuals with asymptomatic malaria displayed multiple significant interactions involving IL-4. Subjects with mild or severe non-lethal malaria displayed substantial loss of interactions in the networks and TNF had significant associations more frequently with other parameters. Cases of lethal P. vivax malaria infection were associated with significant interactions between TNF ALT, HO-1 and SOD-1. Conclusions: The findings imply that clinical immunity to P. vivax malaria is associated with multiple significant interactions in the network, mostly involving IL-4, while lethality is linked to a systematic reduction of complexity of these interactions and to an increase in connections between markers linked to haemolysis-induced damage.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationUniversidade de São Paulo. Instituto de Matemática e Estatística. São Paulo, SP, Brasil / Universidade Tecnológica Federal do Paraná. Coordenação de Informática. Cornélio Procópio, Brasil
dc.creator.affilliationNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, MD, USA
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil
dc.subject.enMalaria
dc.subject.enPlasmodium vivax
dc.subject.enBiomarkers
dc.subject.enNetwork analysis
Appears in Collections:BA - IGM - Artigos de Periódicos

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