Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7297
Title: Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
Authors: Cunha, Liliane Monteiro
Bittencourt, Paulo Lisboa
Lemos, Clarice P. Abrantes
Moreira, Agnaluce
Almeida, Delvone
Paraná, Raymundo
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Portuguese Hospital of Salvador. Salvador, BA, Brasil
University of São Paulo School of Medicine. São Paulo, SP, Brasil
LPC Laboratory. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Non-organ-specific autoantibodies (NOSA) are well-recognized diagnostic markers of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC), but can also be observed in patients with viral hepatitis as well as in healthy subjects. The aim of this study was to evaluate the prevalence of NOSA in subjects living in a rural community in Brazil and to correlate their occurrence with the presence of liver disease. Seven hundred twenty-five apparently healthy subjects were randomly selected for assessment of antinuclear (ANA), anti-smooth muscle (SMA), antimitochondrial (AMA), anti-liver/kidney microsome type 1, and anti-liver cytosol type 1 antibodies. Subjects with those NOSA were evaluated for the presence of AIH, PBC, and viral hepatitis. Reactivities for all NOSA, SMA, ANA, and AMA were detected, respectively, in 14, 10, 4, and 0.1% of subjects, with a mean titer of 1:40. NOSA-positive subjects were significantly older and more frequently females. No correlation was observed between the occurrence of NOSA and PBC, AIH, or viral hepatitis. The prevalence of NOSA in Brazilians was 14%. They were usually low titer. NOSA were more frequently observed in females and older subjects and their presence was not correlated with the presence of AIH, PBC, or viral hepatitis
Keywords: Autoantibodies
Rural population
Autoimmunity
Autoimmune diseases
Liver diseases
Cirrose Hepática Biliar/imunologia
População Rural/estatística & dados numéricos
Anticorpos Antinucleares/imunologia
Adolescente
Adulto
Idoso
Criança
Feminino
Técnica Indireta de Fluorescência para Anticorpo
Hepatite Autoimune/diagnóstico
Hepatite Viral Humana/diagnóstico
Humanos
Cirrose Hepática Biliar/diagnóstico
Mitocôndrias/imunologia
Músculo Liso/imunologia
Prevalência
Adulto jovem
DeCS: Autoanticorpos/imunologia
Hepatite Autoimune/imunologia
Hepatite Viral Humana/imunologia
Issue Date: 2012
Publisher: Elsevier
Citation: CUNHA, L. M. et al. Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study. Human Immunology, v.73, n. 1, p. 70-74, 2012.
ISSN: 1879-1166
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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