| Author | Nicol, Alcina F. | |
| Author | Rodrigues Cordovil Pires, Andréa | |
| Author | de Souza, Simone R. | |
| Author | Nuovo, Gerard J. | |
| Author | Grinsztejn, Beatriz | |
| Author | Tristão, Aparecida | |
| Author | Russomano, Fábio Bastos | |
| Author | Velasque, Luciane | |
| Author | Lapa e Silva, José R. | |
| Author | Pirmez, Claude | |
| Access date | 2014-02-20T14:24:07Z | |
| Available date | 2014-02-20T14:24:07Z | |
| Document date | 2008 | |
| Citation | NICOL, Alcina F. et al. Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA). BMC Cancer, London, v. 8, n. 289, p. 1-10, 2008. | pt_BR |
| ISSN | 1471-2407 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7342 | |
| Sponsorship | PN-DST/AIDS-MS-UNESCO, FAPERJ e IOC-FIOCRUZ | pt_BR |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
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| Rights | open access | pt_BR |
| Title | Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA) | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/1471-2407-8-289 | |
| Abstract | Background
The oncoproteins of human papillomavirus (HPVs) directly effect cell-cycle control. We hypothesize that regulatory and cell cycle protein expression might be additionally modified in the cervix of HIV/HPV co-infected women.
Methods
We analyzed the expression of Rb, p27, VEGF and Elf-1 transcriptor factor by immunohistochemistry in 163 paraffin-embeded cervical samples using Tissue Micro-Array (TMA) and correlated this to HIV-1 and HPV infection.
Results
HIV/HPV co-infection was associated with a significant increase in expression (p < 0.001) of VEGF and p27 in both low and high grade CIN when compared to the cervices of women infected by HPV alone. Decreased Rb expression was evident with increased CIN grade in the cervices of women infected with HPV alone (p = 0.003 average of cells/mm2 in CIN I: 17.9, CIN II/III: 4.8, and tumor 3.9). Rb expression increased 3-fold for both low and high grade CIN with HPV/HIV-1 co-infection compared to HPV infection alone but did not reach statistical significance. There was a significant increase in Elf-1 expression in HPV+/HIV- women with CIN II/III and tumor (average of cells/mm2 in CIN I: 63.8; CIN II/III: 115.7 and tumor: 112.0, p = 0.005), in comparison to controls.
Conclusion
Co-infection of HPV and HIV leads to significant increase in the VEGF and p27 expression when compared to HPV+/HIV-negative infection that could facilitate viral persistence and invasive tumor development. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Niterói, RJ, Brasil. / Laboratório Fonte Medicina Diagnóstica, Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Niterói, RJ, Brasil. / Laboratório Fonte Medicina Diagnóstica, Niterói, RJ, Brasil. | pt_BR |
| Affilliation | University Hospitals Columbus, Department of Pathology, Columbus, Ohio, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. / Universidade Federal do Rio de Janeiro, Departamento de Matemática e Estatística. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. / Universidade Federal do Rio de Janeiro, Departamento de Matemática e Estatística. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento Multidisciplinar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| DeCS | Colo do Útero | pt_BR |
| DeCS | Papillomavirus Humano 11 | pt_BR |
| DeCS | Infecções por HIV - transmissão | pt_BR |
| DeCS | Infecções por HIV - diagnóstico | pt_BR |
