Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7387
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dc.contributor.authorAquino, Dorlene Maria Cardoso de
dc.contributor.authorCaldas, Arlene de Jesus Mendes
dc.contributor.authorMiranda, José Carlos
dc.contributor.authorSilva, Antonio Augusto Moura da
dc.contributor.authorBarral Netto, Manoel
dc.contributor.authorBarral, Aldina Maria Prado
dc.date.accessioned2014-03-10T17:04:07Z
dc.date.available2014-03-10T17:04:07Z
dc.date.issued2010
dc.identifier.citationAQUINO, D. M. C. et al. Epidemiological study of the association between anti-Lutzomyia longipalpis saliva antibodies and development of delayed-type hypersensitivity to Leishmania antigen. American Journal of Tropical Medicine and Hygiene, v.83, n. 4, p.825-827, 2010.
dc.identifier.issn1476-1645
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/7387
dc.language.isoeng
dc.publisherThe American Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.titleEpidemiological study of the association between anti-Lutzomyia longipalpis saliva antibodies and development of delayed-type hypersensitivity to Leishmania antigen
dc.typeArticle
dc.identifier.doi10.4269/ajtmh.2010.10-0182
dc.description.abstractenRecent reports from animal models and from cross-sectional studies have suggested that host responses to anti-Lutzomyia longipalpis saliva antibodies may be related to delayed-type hypersensitivity to Leishmania antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to Leishmania antigen, measured at the 24th follow-up month, was higher among those reactive to Lu. longipalpis saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) (P value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti-Leishmania response.
dc.creator.affilliationUniversidade Federal do Maranhão. Departamento de Enfermagem. São Luís, MA, Brasil
dc.creator.affilliationUniversidade Federal do Maranhão. Departamento de Enfermagem. São Luís, MA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imuno-regulação. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia iii - INCT. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunoparasitologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia iii - INCT. Salvador, BA, Brasil
dc.subject.decsAnticorpos/sangue
dc.subject.decsAntígenos de Protozoários/imunologia
dc.subject.decsHipersensibilidade Tardia/etiologia
dc.subject.decsLeishmania/imunologia
dc.subject.decsLeishmaniose Visceral/diagnóstico
dc.subject.decsPsychodidae/imunologia
dc.subject.decsAnimais
dc.subject.decsCriança
dc.subject.decsPré-Escolar
dc.subject.decsEstudos de Coortes
dc.subject.decsHumanos
dc.subject.decsHipersensibilidade Tardia/imunologia
dc.subject.decsLactente
dc.subject.decsLeishmaniose Visceral/imunologia
dc.subject.decsRecém-Nascido
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