Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7406
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dc.contributor.authorReis, Eliana Almeida Gomes
dc.contributor.authorAthanazio, Daniel Abensur
dc.contributor.authorCavada, Benildo Sousa
dc.contributor.authorTeixeira, Edson Holanda
dc.contributor.authorPinto, Vicente de Paulo Teixeira
dc.contributor.authorCarmo, Theomira Mauadie de Azevedo
dc.contributor.authorReis, Alice
dc.contributor.authorTrocolli, Graziela
dc.contributor.authorCroda, Julio Henrique Rosa
dc.contributor.authorHarn Junior, Donald A
dc.contributor.authorBarral Netto, Manoel
dc.contributor.authorReis, Mitermayer Galvão dos
dc.date.accessioned2014-03-13T18:51:28Z
dc.date.available2014-03-13T18:51:28Z
dc.date.issued2008
dc.identifier.citationREIS, E. A. G. et al. Potential immunomodulatory effects of plant lectins in Schistosoma mansoni infection. Acta Tropica, v. 108, n. 2/3, p. 160-165, 2008.
dc.identifier.issn1873-6254
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/7406
dc.language.isoeng
dc.publisherElsevier B.V
dc.rightsopen access
dc.titlePotential immunomodulatory effects of plant lectins in Schistosoma mansoni infection
dc.typeArticle
dc.identifier.doi10.1016/j.actatropica.2008.05.025
dc.description.abstractenLectins are sugar-binding glycoproteins that can stimulate, in a non-antigen-specific fashion, lymphocytes, leading to proliferation and cytokine production. Some lectins are utilized as in vitro mitogenic lymphocyte stimulators and their use as immunomodulators against infectious diseases has been evaluated experimentally. In the experimental murine model, the immune response to schistosomiasis is Th1-like during the initial stage of infection, with a shift towards a Th2-like response after oviposition. We report the response of schistosomiasis patients' (n=37) peripheral blood mononuclear cells (PBMC) to stimulation by lectins, including newly isolated lectins from Brazilian flora, and by Schistosomamansoni soluble egg antigens (SEA). Cytokine production upon lectin stimulation ex vivo was assessed in PBMC supernatants, collected at 24 and 72 h, by sandwich ELISA to IL-5, IL-10, TNF-alpha and IFN-gamma. In PBMC from infected patients all but one of the lectins induced a Th2-like cytokine response, characterized by elevated IL-5 production that was higher than that induced by SEA stimulation alone. Our results show that the Th2 environment present during schistosomiasis is not affected and that it may be further stimulated by the presence of lectins.
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal do Ceará. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, Brasil
dc.creator.affilliationUniversidade Federal de Ceará. Faculdade de Medicina. Sobral, CE, Brasil
dc.creator.affilliationUniversidade Federal de Ceará. Faculdade de Medicina. Sobral, CE, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationHarvard School of Public Health. Department of Immunology and Infectious Diseases. Boston, USA
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enLectins
dc.subject.enSchistosoma mansoni
dc.subject.enCytokines
dc.subject.decsFatores Imunológicos/farmacologia
dc.subject.decsLectinas/farmacologia
dc.subject.decsLeucócitos Mononucleares/efeitos de drogas
dc.subject.decsLeucócitos Mononucleares/imunologia
dc.subject.decsEsquistossomose mansoni/imunologia
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsAnimais
dc.subject.decsCélulas Cultivadas
dc.subject.decsCriança
dc.subject.decsCitocinas/secreção
dc.subject.decsEnsaio de Imunoadsorção Enzimática
dc.subject.decsFeminino
dc.subject.decsHumanos
dc.subject.decsMasculino
dc.subject.decsMeia-Idade
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