Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/7411
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dc.contributor.authorArruda, Maria da Gloria Bomfim
dc.contributor.authorAndrade, Bruno de Bezerril
dc.contributor.authorSantos, Silvane
dc.contributor.authorClarêncio, Jorge
dc.contributor.authorBarral Netto, Manoel
dc.contributor.authorBarral, Aldina Maria Prado
dc.date.accessioned2014-03-17T17:07:05Z
dc.date.available2014-03-17T17:07:05Z
dc.date.issued2007
dc.identifier.citationBOMFIM, G. et al. Cellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease. American Journal of Tropical Medicine Hygiene, v. 77, n. 5, p. 854–859, 2007.
dc.identifier.issn1476-1645
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/7411
dc.language.isoeng
dc.publisherThe American Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.titleCellular analysis of cutaneous leishmaniasis lymphadenopathy: insights into the early phases of human disease.
dc.typeArticle
dc.description.abstractenLymphadenopathy is an early clinical sign in cutaneous leishmaniasis (CL), caused by Viannia parasites, and may help to understand the initial host response to these species of Leishmania. We report on characteristics of cells obtained from lymph nodes from cutaneous leishmaniasis patients with lymphadenopathy without ulceration (early phase, N = 21) or lymphadenopathy and ulceration (late phase, N = 29). Early-phase patients exhibited a higher proportion of neutrophils, eosinophils, and CD8+ T cells. Conversely, CD19+ B lymphocytes and plasma cells were more frequently observed in late-phase patients. The signal for IL-10 was significantly higher in late-phase patients; signals for IFN-gamma or IL-4 were similar in both groups. These data reinforce observations of an initial mixed Th1-Th2 profile as well as the early role of the CD8 T cell in cutaneous leishmaniasis. Additionally, there is a chronologic relationship between ulcer development and B-cell increase. IL-10 also increases at a late stage and may be important in limiting tissue damage.
dc.creator.affilliationHospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationHospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Instituto do Milênio. Salvador, BA, Brasil
dc.subject.decsLeishmaniose Cutânea/patologia
dc.subject.decsLinfonodos/citologia
dc.subject.decsDoenças Linfáticas/patologia
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsCrianças
dc.subject.decsHumanos
dc.subject.decsFeminino
dc.subject.decsMasculino
dc.subject.decsMeia-Idade
dc.subject.decsPele/patologia
Appears in Collections:BA - IGM - Artigos de Periódicos

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