Author | Campanelli, Ana Paula | |
Author | Roselino, Ana Maria Ferreira | |
Author | Cavassani, Karen Angélica | |
Author | Pereira, Marcelo de Souza Fernandes | |
Author | Mortara, Renato Arruda | |
Author | Brodskyn, Claudia Ida | |
Author | Gonçalves, Heitor de Sá | |
Author | Belkaid, Yasmine | |
Author | Barral Netto, Manoel | |
Author | Barral, Aldina Maria Prado | |
Author | Silva, João Santana da | |
Access date | 2014-03-17T18:36:18Z | |
Available date | 2014-03-17T18:36:18Z | |
Document date | 2006 | |
Citation | CAMPANELLI, A. P. et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. The Journal of Infectious Diseases, v. 193, n. 9, p. 1313–1322, 2006. | pt_BR |
ISSN | 0022-1899 | |
URI | https://www.arca.fiocruz.br/handle/icict/7413 | |
Language | eng | pt_BR |
Publisher | the Infectious Diseases Society of America. | pt_BR |
Rights | open access | pt_BR |
Title | CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. | pt_BR |
Type | Article | pt_BR |
Abstract | Endogenous regulatory T (Treg) cells are involved in the control of infections, including Leishmania infection
in mice. Leishmania viannia braziliensis is the main etiologic agent of cutaneous leishmaniasis (CL) in Brazil,
and it is also responsible for the more severe mucocutaneous form. Here, we investigated the possible involvement
of Treg cells in the control of the immune response in human skin lesions caused by L. viannia
braziliensis infection. We show that functional Treg cells can be found in skin lesions of patients with CL. These
cells express phenotypic markers of Treg cells—such as CD25, cytotoxic T lymphocyte–associated antigen 4,
Foxp3, and glucocorticoid-induced tumor necrosis factor receptor—and are able to produce large amounts
of interleukin-10 and transforming growth factor–b. Furthermore, CD4+CD25+ T cells derived from the skin
lesions of 4 of 6 patients with CL significantly suppressed in vitro the phytohemagglutinin-inducedproliferative
T cell responses of allogeneic peripheral-blood mononuclear cells (PBMCs) from healthy control subjects at
a ratio of 1 Treg cell to 10 allogeneic PBMCs. These findings suggest that functional Treg cells accumulate at
sites of Leishmania infection in humans and possibly contribute to the local control of effector T cell functions | pt_BR |
Affilliation | University of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | University of São Paulo. School of Medicine of Ribeirão Preto. Division of Dermatology. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | University of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | University of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | Universidade Federal de São Paulo. Department of Microbiology, Immunology, and Parasitology. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute of Investigation in Immunology. Salvador, BA, Brasil | pt_BR |
Affilliation | Center for Dermatology Dona Libânia. Fortaleza, CE, Brasil | pt_BR |
Affilliation | National Institutes of Health. Mucosal Immunology Unit. Laboratory of Parasitic Diseases. Bethesda, MD | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute of Investigation in Immunology. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute of Investigation in Immunology. Salvador, BA, Brasil | pt_BR |
Affilliation | University of São Paulo. School of Medicine of Ribeirão Preto. Department of Biochemistry and Immunology and Division of Dermatology. Ribeirão Preto, SP, Brasil | pt_BR |
DeCS | Antígenos CD4/análise | pt_BR |
DeCS | Leishmania braziliensis | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Receptores de Interleucina-2/análise | pt_BR |
DeCS | Pele/imunologia | pt_BR |
DeCS | Linfócitos T Reguladores/imunologia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Quimiocinas CC/metabolismo | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Fatores de Transcrição Forkhead/metabolismo | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imunossupressão | pt_BR |
DeCS | Interleucina-10/metabolismo | pt_BR |
DeCS | Leishmaniose Cutânea/patologia | pt_BR |
DeCS | Ativação Linfocitária | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Fenótipo | pt_BR |
DeCS | Receptores CCR4 | pt_BR |
DeCS | Receptores de Quimiocinas/metabolismo | pt_BR |
DeCS | Pele/microbiologia | pt_BR |
DeCS | Pele/patologia | pt_BR |
DeCS | Linfócitos T Reguladores/citologia | pt_BR |
DeCS | Fator de Crescimento Transformador beta/metabolismo | pt_BR |