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| Autor | Tartof, Sara Yee | |
| Autor | Reis, Joice Neves | |
| Autor | Andrade, Aurelio Nei | |
| Autor | Ramos, Regina Terse Trindade | |
| Autor | Reis, Mitermayer Galvão dos | |
| Autor | Riley, Lee Woodland | |
| Fecha de acceso | 2014-04-08T16:31:04Z | |
| Fecha de disponibilización | 2014-04-08T16:31:04Z | |
| Fecha de publicación | 2010 | |
| Referencia | TARTOF, S. Y. et al. Factors associated with Group A Streptococcus emm type diversification in a large urban setting in Brazil: a cross-sectional study. BMC Infectious Diseases, v. 10, p. 327, 2010. | pt_BR |
| ISSN | 1471-2334 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7504 | |
| Idioma | eng | pt_BR |
| Editor | BioMed Central | pt_BR |
| Derechos de autor | open access | pt_BR |
| Título | Factors associated with Group A Streptococcus emm type diversification in a large urban setting in Brazil: a cross-sectional study. | pt_BR |
| Tipo del documento | Article | pt_BR |
| Resumen en Inglés | Group A Streptococcus (GAS) strain diversity varies across different regions of the world, according to low versus high-income countries. These differences may be related to geographic, environmental, socioeconomic, or host-related factors. However, local factors may also affect strain diversity. We compared the emm types of GAS isolates from children with and without sore throat in one large urban setting in Brazil. METHODS: Children 3-15 years of age were consecutively recruited from slum and non-slum pediatric outpatient clinics between April-October, 2008. Throat cultures were performed and data intake forms were completed. GAS isolates were typed by emm sequencing. RESULTS: From 2194 children, 254 (12%) GAS isolates were obtained. Of 238 GAS isolates that were emm-typed, 61 unique emm types were identified. Simpson's diversity index of the emm types was higher among isolates from slum children [97% (96%-98%)] than those of non-slum children [92% (89%-96%)]. Two emm types (66.0, 12.0) were more frequently isolated from children with sore throat (p < 0.05), and one emm type (27G.0) demonstrated a protective effect. CONCLUSIONS: The emm type diversity from children attending slum clinics resembled the emm diversity of low income countries rather than that of children attending a non-slum clinic in the same city. Local factors, such as crowding, may enhance the frequency of GAS transmission and horizontal gene transfers that contribute to increased strain diversity in the slums. GAS vaccine coverage and control of GAS infections will need to take these local factors and strain differences into consideration. | pt_BR |
| Afiliación | University of California Berkeley. School of Public Health. USA. | pt_BR |
| Afiliación | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Afiliación | Hospital São Rafael-Monte Tabor. Salvador, BA, Brasil | pt_BR |
| Afiliación | Federal University of Bahia School of Medicine. Department of Pediatrics. Salvador, BA, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliación | University of California Berkeley. School of Public Health. USA. | pt_BR |
| DeCS | Variação Genética | pt_BR |
| DeCS | Infecções Estreptocócicas/epidemiologia | pt_BR |
| DeCS | Streptococcus pyogenes/genética | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Técnicas de Tipagem Bacteriana | pt_BR |
| DeCS | Brasil/epidemiologia | pt_BR |
| DeCS | Criança | pt_BR |
| DeCS | Pré-Escolar | pt_BR |
| DeCS | Estudos Transversais | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Genótipo | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Faringite | pt_BR |
| DeCS | Áreas de Pobreza | pt_BR |
| DeCS | Infecções Estreptocócicas/microbiologia | pt_BR |
| DeCS | Streptococcus pyogenes/classificação | pt_BR |
| DeCS | Streptococcus pyogenes/isolamento & purificação | pt_BR |
| DeCS | População Urbana | pt_BR |
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