Author | Zarife, Maria Alice Sant’Anna | |
Author | Reis, Eliana Almeida Gomes | |
Author | Carmo, Theomira Mauadie de Azevedo | |
Author | Lopes, Gisele Barreto | |
Author | Brandão, Emilia Carolina Malafaia | |
Author | Silva, Helder Reis | |
Author | Santana, Nelma Pereira de | |
Author | Martins Filho, Olindo Assis | |
Author | Reis, Mitermayer Galvão dos | |
Access date | 2014-04-14T16:52:19Z | |
Available date | 2014-04-14T16:52:19Z | |
Document date | 2009 | |
Citation | ZERIFE, M. A. S. et al. Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Virology, v. 81, n. 1, p. 49-59, 2009. | pt_BR |
ISSN | 1096-9071 | |
URI | https://www.arca.fiocruz.br/handle/icict/7516 | |
Language | eng | pt_BR |
Publisher | Wiley Periodicals, Inc. | pt_BR |
Rights | open access | pt_BR |
Title | Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56- NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/jmv.21340 | |
Abstract | A detailed phenotypic analysis of major and minor circulating lymphocyte subsets is described in potential blood donors with markers of hepatitis C virus (HCV), including non-viremic and viremic groups. Although there were no changes in the hematological profile of either group, increased the levels of pre-NK cells (CD3-CD16+CD56-) and a lower frequency of mature NK cells (CD3-CD16+CD56+) characterized innate immunity in the non-viremic group. Both non-viremic and viremic groups displayed significantly increased levels of CD56(Bright) NK cells. Furthermore, this subset was significantly elevated in the viremic subgroup with a low viral load. In addition, an increase in the NKT2 subset was observed only in this subgroup. An enhanced frequency of activated CD4+ T-cells (CD4+HLA-DR+) was a characteristic feature of the non-viremic group, whereas elevated CD19+ B-cells and CD19+CD86+ cell populations were the major phenotypic features of the viremic group, particularly in individuals with a low viral load. Although CD4+CD25High T-cells were significantly elevated in both the viremic and non-viremic groups, it was particularly evident in the viremic low viral load subgroup. A parallel increase in CD4+CD25High T-cells, pre-NK, and activated CD4+ T-cells was observed in the non-viremic group, whereas a parallel increase in CD4+CD25High T-cells and CD19+ B-cells was characteristic of the low viral load subgroup. These findings suggest that CD56Bright NK cells, together with pre-NK cells and activated CD4+ T-cells in combination with CD4+CD25High T-cells, might play an important role in controlling viremia. Elevated CD56(Bright) NK cells, B-cell responses and a T-regulated immunological profile appeared to be associated with a low viral load | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Laboratório Central de Saúde Pública Prof. Gonçalo Moniz (LACEN-BA). Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | HCV | pt_BR |
Subject | Blood donors | pt_BR |
Subject | NK and NKT cells; | pt_BR |
Subject | Activated T and B cells | pt_BR |
Subject | CD4+CD25High | pt_BR |
DeCS | Antígenos CD/análise | pt_BR |
DeCS | Linfócitos B/imunologia | pt_BR |
DeCS | Doadores de Sangue | pt_BR |
DeCS | Linfócitos T CD4-Positivos/imunologia | pt_BR |
DeCS | Hepatite C Crônica/imunologia | pt_BR |
DeCS | Células Matadoras Naturais/imunologia | pt_BR |
DeCS | Subpopulações de Linfócitos/imunologia | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Hepacivirus/isolamento & purificação | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Células Matadoras Naturais/química | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Carga Viral | pt_BR |
DeCS | Viremia/imunologia | pt_BR |